Cisplatin (DDP) is widely used in the treatment of cancer as a chemotherapeutic drug.
However, its severe nephrotoxicity limits the extensive application of cisplatin, which is …

Cisplatin is one of the most commonly used and highly effective cancer chemotherapeutic
agents. Use of cisplatin is limited due to persistence of severe side effects such as …

This study was performed to examine whether clindamycin could protect against doxorubicin
(DOX)-induced acute nephrotoxicity, and if so, what molecular mechanisms responsible for …

Nephrotoxicity is one of major side effects of cisplatin in chemotherapy. Therefore, there is
an urgent medical need to develop drugs that may protect kidney from toxicity. In previous …

Oxaliplatin (OXL) is a significant therapy agent for the worldwide increase in cancer cases.
Naringin (4′, 5, 7‐trihydroxy flavonon 7‐rhamnoglucoside, NRG) has a wide range of …

Background Doxorubicin is an anthracycline antitumor agent commonly used in clinical
practice, which has some nephrotoxicity and is often used to establish mouse models of …

Background Cisplatin is effective against various types of cancers. However, its clinical
application is limited owing to its adverse effects, especially acute kidney injury (AKI) …

Cisplatin (CP) is a chemotherapeutic drug used to treat solid tumors. However, studies have
revealed its nephrotoxic effect. Oxidative stress, endoplasmic reticulum (ER) stress, and …

Oridonin has been shown to exhibit therapeutic effects against hepatocellular carcinoma
(HCC) in vitro and in vivo. This study aimed to identify the anti-HCC mechanisms of oridonin …

We investigated the protective effects exerted by oridonin, the main active constituent of the
Chinese medicinal herb Rabdosiarubescens, against lipopolysaccharide (LPS)/D …