We have explored the fundamental biological processes by which complex carbohydrates
expressed on cellular glycoproteins and glycolipids and in secretions of cells promote cell …

Glycosylation produces a diverse and abundant repertoire of glycans, which are collectively
known as the glycome. Glycans are one of the four fundamental macromolecular …

Unlike their protein “roommates” and their nucleic acid “cousins," carbohydrates remain an
enigmatic arm of biology. The central reason for the difficulty in fully understanding how …

Leukocyte recruitment encompasses cell adhesion and activation steps that enable
circulating leukocytes to roll, arrest, and firmly adhere on the endothelial surface before they …

Galectins compose a protein family defined by a conserved sequence motif conferring
affinity for β-galactose–containing glycans. Moreover, galectins gain higher affinity and fine …

Mammalian glycan‐binding receptors, sometimes known as lectins, interact with glycans,
the oligosaccharide portions of endogenous mammalian glycoproteins and glycolipids as …

The vast range and complexity of glycan structures and their dynamic variations in health
and disease have presented formidable challenges toward understanding the biological …

Virtually all cells and extracellular material are heavily decorated by various glycans, yet our
understanding of the structure and function of these moieties lags behind the understanding …

Glycans and complementary glycan-binding proteins are essential components in the
language of cell-cell interactions in immunity. The study of glycan function is the purview of …

Over the last decade, we have witnessed an explosion of information regarding the function
of glycoconjugates, carbohydrate-binding proteins, and the elucidation of the sugar code …