We have investigated the role of reactive oxygen species (ROS) in cell death induced by
ischemia or application of the excitatory amino acid agonist, N-methyl-D-aspartate (NMDA) …

When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5
mM KCl (K5) caspase‐3 and caspase‐8, but not caspase‐1 or caspase‐9, activities are …

Cerebellar granule neurons undergo apoptosis when deprived of chronic depolarization;
serum deprivation has not been considered as a trigger of apoptosis in this culture. Here we …

That glutamate increases in the extracellular space of the brain during hypoxia or ischemia
and that this amino acid, in high enough concentrations, kills neurons has led investigators …

The effects of various pathogenic factors on the viability of cultured immature and mature
granule cells of rat cerebellum that developed during brain hypoxia and reoxygenation were …

In cultured rat cerebellar granule cells, glutamate or N-methyl-d-aspartate (NMDA) activation
of the NMDA receptor caused a sustained increase in cytosolic Ca2+ levels ([Ca2+] i) …

On exposure to glutamate, cultured rat cerebellar granule cells undergo a delayed Ca2+
deregulation (DCD), which precedes and predicts cell death. We have previously shown that …

When embryonic rat hippocampal neurons were cultured in a 50% oxygen atmosphere,
neurons gradually died after 20 h in culture. This death pattern was found to be mediated by …

Reactive oxygen species (ROS) production in rat cerebellar granule cells in the presence of
the excitotoxinsN-methyl-d-aspartate (NMDA) and kainic acid (KA) and by the protein kinase …

Apoptosis is characterized by chromatin condensation, phosphatidylserine translocation,
and caspase activation. Neuronal apoptotic death involves the participation of reactive …