We investigate the death route induced by potassium depletion in cerebellar granule cells in
0–15 h time range and study whether and how mutual relationship occurs between the cell …

Induction of chemical anoxia, using sodium azide in cerebellar granule cells maintained in
primary culture, was evaluated as an in vitro assay for screening of potential neuroprotective …

Enhanced production of superoxide anion (O2−) is considered to play a pivotal role in the
pathogenesis of CNS neurons. Here, we report that O2− generated by xanthine (XA)+ …

Nitric oxide (NO) has been proposed as a neuronal messenger molecule in
hypoxic/ischemic cell injury (Nowicki et al., 1991; Trifiletti, 1992). We conducted studies in a …

We analyzed biochemically and temporally the molecular events that occur in the
programmed cell death of mouse cerebellar granule neurons deprived of high potassium …

Cultured rat cerebellar granule neurons are widely used as a model system for studying
neuronal apoptosis. Either low K+ (5 mM) or low concentrations of glutamate (1–10 μM) …

The type of cell death encountered in neuronal cell cultures exposed to excitatory amino
acids—such as glutamate, the major excitatory neurotransmitter in the central nervous …

In neurons, oxidative stress can be triggered by neurotransmitter-linked mechanisms and
may lead to apoptotic cell death. A simple and reproducible model of inducing oxidative …

The present study investigated the temporal relationship between neuronal nitric oxide
synthase (nNOS) activity and expression and the development of neuronal damage …

APOPTOTIC DEATH IN AN IN VITRO MODEL OF NEURONAL OXIDATIVE STRESS Page 1
Clinical and Experimental Pharmacology and Physiology (1995) 22,309-3 10 APOPTOTIC …