From 1 to 3 h after the onset of cerebellar granule cells (CGC) apoptosis in a low‐K+ (5 mm
KCl) medium there was a large decay of NADH and a 2.5‐fold increase of the rate of …

An in vitro system was used to mimic several aspects of ischemia, including low oxygen
pressure, low nutrient levels, and the accumulation of cellular products thought to contribute …

Publisher Summary Elucidation of cellular and molecular mechanisms of excitotoxic
neuronal injury have been facilitated by the development of several cell biological …

In cerebellar granule cells in culture, lowering of extracellular [K+] results in apoptotic death
(D'Mello, SR, Galli, C., Ciotti, T. and Calissano, P., Induction of apoptosis in cerebellar …

During the development of the nervous system, a large number of neurons are eliminated
through naturally occurring neuronal death. Many morphological and biochemical properties …

Reactive oxygen species (ROS) may be generated by toxins, ischemidanoxia, ionizing
radiation and other forms of xenobiotic-induced cell injury. Changes in the state of oxidative …

The relationship is investigated between superoxide levels in single cultured rat cerebellar
granule neurons exposed continuously to glutamate in low KCl medium and the …

Cerebellar granule cells maintained in medium containing serum and 25 mm potassium
undergo an apoptotic death within 96 hr when switched to serum-free medium with 5 mm …

Cultured cerebellar granule cells deprived of depolarizing concentrations of KCl and serum
die by programmed cell death. Recently, it was shown that serum removal by itself can lead …

Production of oxygen free radicals is a natural consequence of aerobic metabolism and they
are constantly generated in vivo by chemical reactions and metabolic processes. Antioxidant …