Free radicals and neuronal cell death.
Production of oxygen free radicals is a natural consequence of aerobic metabolism and they
are constantly generated in vivo by chemical reactions and metabolic processes. Antioxidant …
are constantly generated in vivo by chemical reactions and metabolic processes. Antioxidant …
Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species
A Boldyrev, R Song, D Lawrence, DO Carpenter - Neuroscience, 1999 - Elsevier
The role of carnosine, N-acetylcarnosine and homocarnosine as scavengers of reactive
oxygen species and protectors against neuronal cell death secondary to excitotoxic …
oxygen species and protectors against neuronal cell death secondary to excitotoxic …
Cell death in primary cultures of mouse neurons and astrocytes during exposure to and 'recovery'from hypoxia, substrate deprivation and simulated ischemia
E Sochocka, BHJ Juurlink, WE Code, V Hertz, L Peng… - Brain research, 1994 - Elsevier
Abstract Effects of hypoxia, substrate deprivationand simulated ischemia (combined hypoxia
and substrate deprivation) on cell survival during the insult itself and during a 24 h …
and substrate deprivation) on cell survival during the insult itself and during a 24 h …
Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons
GM Yan, B Ni, M Weller, KA Wood, SM Paul - Brain research, 1994 - Elsevier
Cerebellar granule neurons can be readily maintained in culture if depolarized with high
concentrations of K+ or subtoxic concentrations of various excitatory amino acids. We now …
concentrations of K+ or subtoxic concentrations of various excitatory amino acids. We now …
■ REVIEW: Excitotoxicity, Free Radicals, Necrosis, and Apoptosis
SA Lipton, P Nicotera - The Neuroscientist, 1998 - journals.sagepub.com
Recent studies have shown that excitotoxicity can result in either neuronal necrosis (passive
cell lysis associated with energy failure) or apoptosis (active cell death requiring energy …
cell lysis associated with energy failure) or apoptosis (active cell death requiring energy …
Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons
A Coyoy, A Valencia, A Guemez-Gamboa… - Free Radical Biology and …, 2008 - Elsevier
Cerebellar granule neurons (CGN) cultured in a medium containing 25 mM KCl and treated
with staurosporine (ST) or transferred to a medium with 5 mM KCl (K5) die apoptotically …
with staurosporine (ST) or transferred to a medium with 5 mM KCl (K5) die apoptotically …
Cellular and molecular events of ischemic brain damage.
C Cafe, C Torri, F Marzatico - Functional neurology, 1993 - europepmc.org
Many events occurring during and after cerebral ischemia are well known, but they are not
known enough to fully elucidate the mechanisms of brain damage. Energy failure alone …
known enough to fully elucidate the mechanisms of brain damage. Energy failure alone …
Dissociation of nitric oxide generation and kainate-mediated neuronal degeneration in primary cultures of rat cerebellar granule cells
PS Puttfarcken, WE Lyons, JT Coyle - Neuropharmacology, 1992 - Elsevier
In the presence of physiological concentrations of Mg 2+ and in glycine-free buffer, the
relationship between KA-mediated generation of NO and neurotoxicity in cultures of …
relationship between KA-mediated generation of NO and neurotoxicity in cultures of …
Cell culture studies of the role of elevated extracellular glutamate and K+ in neuronal cell death during and after anoxia/ischemia
R HUANG, E SOCHOCKA, L HERTZ - Neuroscience & Biobehavioral …, 1997 - Elsevier
HUANG, R., E. SOCHOCHKA AND L. HERTZ. Cell culture studies of the role of elevated
extracellular glutamate and K+ in neuronal cell death during and after anoxia/ischemia …
extracellular glutamate and K+ in neuronal cell death during and after anoxia/ischemia …
Evaluation of free radical production, mitochondrial membrane potential and cytoplasmic calcium in mammalian neurons by flow cytometry
The overexcitation of glutamate receptors is believed to be the cause of several
neurodegenerative disorders. The determination of calcium fluxes, mitochondrial membrane …
neurodegenerative disorders. The determination of calcium fluxes, mitochondrial membrane …