Depolarizing concentrations of potassium (K+) promote maturation and survival of cerebellar
granule neurons in vitro. Withdrawal of potassium from differentiated neurons induces …

Neuronal death, attributable to perturbed redox homeostasis, is the underlying factor in
many acute and chronic neurological disorders. The mechanisms employed by oxidatively …

N-Methyl-D-aspartate (NMDA) receptor-mediated neurotoxicity may depend, in part, on the
generation of nitric oxide (NO.) and superoxide anion (O2.-), which react to form peroxynitrite …

We have shown recently that cerebellar granule neurons die in the absence of depolarizing
concentrations of KCl through an apoptosis-like process. To study the contributions of …

This chapter reviews material presented at the Symposium and also pertinent literature,
seeking answers to three sets of problems: 1. the mechanism of the reversible blockade of …

The effects of the metabotropic glutamate receptor agonists against apoptosis induced by
oxygen–glucose deprivation or colchicine were studied in the primary cultures of mature …

Apoptosis induced by low potassium (K5) or staurosporine in cerebellar granule neurons
triggers an increase in reactive oxygen species (ROS) levels. ROS inhibition by antioxidants …

Oxidative stress is implicated in a number of neurological disorders including stroke,
Parkinson's disease, and Alzheimer's disease. To study the effects of oxidative stress on …

To study the effect of extracellular acidosis on apoptosis and necrosis during ischemia and
reoxygenation, we exposed human post‐mitotic NT2‐N neurones to oxygen and glucose …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …