The implication of reactive oxygen species for the Ca2+ ionophore ionomycin-induced
apoptosis was investigated in cultured cortical neurons from embryonic rats. Ionomycin …

Astrocyte dysfunction and death accompany cerebral ischemia/reperfusion and possibly
compromise neuronal survival. Animal studies indicate that neuronal death, neurologic …

Apoptotic death results from disrupting the balance between anti‐apoptotic and pro‐
apoptotic cellular signals. The inter‐and intracellular messenger nitric oxide is known to …

To study the role of calcium in neuronal death during ischemia, we examined the
characteristics of intracellular Ca 2+([Ca 2+] i) changes in single rat forebrain neurons …

Although it is recognized that ATP plays a part in apoptosis, whether and how its level
changes en route to apoptosis as well as how ATP is synthesized has not been fully …

Oxidative stress, resulting from excessive production of reactive oxygen species (ROS), is a
pathological state that causes profound cellular damage and eventual death resulting from …

Apoptosis is an active, gene-directed process of cell death in which early fragmentation of
nuclear DNA precedes morphological changes in the nucleus and, later, in the cytoplasm. In …

A 100 [mu] M glutamate pulse administered to rat cerebellar granule cells causes a very
rapid and progressive decrease in both cell and mitochondria! oxygen consumption caused …

Flow cytometric studies of rat cerebellum neurons are described under conditions inducing
cell death. Using a double labeling technique, discrimination between apoptotic and …

The aim of this work was to develop a novel procedure useful to detect the formation of two
reactive oxygen species, ie superoxide and singlet oxygen, in neuron monolayer primary …