We have investigated cell killing in cultured rat embryonic cortical neurons exposed to the
protein kinase inhibitor staurosporine, the excitatory amino acid N-methyl-d-aspartate …

Mouse astrocytes in primary cultures were subjected to an in vitro model of ischemia
(hypoxia combined with substrate deprivation, excess potassium, or elevated glutamate) …

Elevated free cytosolic Ca2+ (Ca2+ i) has been implicated as a mechanism of hypoxic
neuronal death. The calcium hypothesis postulates that the basic metabolic response to …

The effects of glucose and O2 deprivation (OGD) on the survival of cortical and cerebellar
neurons were examined to characterize the biochemical mechanisms involved in OGD and …

When excitotoxic mechanisms are blocked, severe or prolonged hypoxia and hypoxia–
ischemia can still kill neurons, by a mechanism which is poorly understood. We studied this …

SIMULTANEOUS measurements of membrane potential and intracellular Ca 2+ were used
to study the effects of hypoxia on striatal and cortical neurones. Striatal neurones responded …

We have previously reported that glutamate can trigger a succession of necrosis and
apoptosis in cerebellar granule cells (CGC). Since specific blockers of the (NMDA) receptor …

Cerebral ischemia followed by oxygen reperfusion induces apoptosis in hippocampal
neurons in stroke-prone spontaneously hypertensive rats (SHRSP) but not in Wistar Kyoto …

Granule cells in a dissociated neuro‐glial cell culture of cerebellum when exposed to
ouabain (10− 3 M) for 25 min apparently swell, increase their [Ca2+] i with obvious …

The relative contribution of sodium, chloride and calcium ions in the neuronal death induced
by glutamate is controversial. We have therefore reassessed the effects of extracellular ion …