OBJECTIVE:: The purpose of this study was to investigate the impact of chronic hypoxia on
the nitric oxide synthase isoenzymes in specific brain structures. STUDY DESIGN:: Time …

Neuronal nitric oxide synthase (nNOS) and nitric oxide (NO) are implicated in neuronal
injury following acute hypoxia-ischemia (HI). Our hypothesis was that NO from nNOS is …

The effects of intrauterine hypoxia–ischemia (HI) on nitric oxide synthase (NOS) activity and
on expression of NOS isoforms were investigated in fetal and neonatal rat brains. Rat …

Objective: To determine whether, and if so how, iNOS expresses and affects brain injury
induced by hypoxia‐ischemia in an immature brain. Material and Methods: Seven‐day‐old …

Free radical-mediated injury is implicated in hypoxic-ischemic encephalopathy observed in
neonates. We investigated in utero free radical production and injury following hypoxia …

Background: Fetal growth restriction is the second leading cause of perinatal morbidity and
mortality, and neonates with intrauterine growth retardation (IUGR) have increased …

We hypothesized that elimination of neuronal nitric oxide synthase (nNOS) by targeted
disruption of the nNOS gene would result in amelioration of damage seen after hypoxia …

Aim: The purpose of the present study was to examine the effect of lipopolysaccharide (LPS)
and intermittent hypoxia–ischemia (HI) on brain damage in neonatal rats. Methods: Seven …

The aim of this study is to quantify the effect of intrauterine hypoxia (HPX) and the role of
nitric oxide (NO) on the apoptotic enzyme, caspase 3, and DNA fragmentation in fetal heart …

It was recently discovered that while under normal conditions inhaled nitric oxide (iNO) does
not affect cerebral blood flow, it selectively dilates arterioles in the ischemic penumbra …