Synergistic interplay of UV radiation and urban particulate matter induces impairment of autophagy and alters cellular fate in senescence‐prone human dermal …

L Guerrero‐Navarro, P Jansen‐Dürr, M Cavinato - Aging Cell, 2024 - Wiley Online Library
Skin aging is a complex process influenced by intrinsic factors and environmental stressors,
including ultraviolet (UV) radiation and air pollution, among others. In this study, we …

UVB-induced senescence of human dermal fibroblasts involves impairment of proteasome and enhanced autophagic activity

M Cavinato, R Koziel, N Romani… - … Series A: Biomedical …, 2017 - academic.oup.com
In the current study, we have extended previous findings aiming at a better understanding of
molecular mechanisms underlying UVB-induced senescence of diploid human dermal …

Elimination of damaged mitochondria during UVB‐induced senescence is orchestrated by NIX‐dependent mitophagy

M Cavinato, I Martic, S Wedel, A Pittl, R Koziel… - Aging …, 2024 - Wiley Online Library
Skin aging is the result of two types of aging,“intrinsic aging” an inevitable consequence of
physiologic and genetically determined changes and “extrinsic aging,” which is dependent …

Autophagy: multiple mechanisms to protect skin from ultraviolet radiation‐driven photoaging

M Wang, P Charareh, X Lei… - Oxidative Medicine and …, 2019 - Wiley Online Library
Autophagy is an essential cellular process that maintains balanced cell life. Restriction in
autophagy may induce degenerative changes in humans. Natural or pathological aging of …

Pharmacological activation of autophagy restores cellular homeostasis in ultraviolet-(B)-induced skin photodamage

SA Umar, NH Shahid, LA Nazir, MA Tanveer… - Frontiers in …, 2021 - frontiersin.org
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as the primary
etiological agent in photo-carcinogenesis. UV-B exposure induces cellular damage and is …

[HTML][HTML] Faces of cellular senescence in skin aging

CY Ho, O Dreesen - Mechanisms of Ageing and Development, 2021 - Elsevier
The skin is comprised of different cell types with different proliferative capacities. Skin aging
occurs with chronological age and upon exposure to extrinsic factors such as photodamage …

Air Pollution, Autophagy, and Skin Aging: Impact of Particulate Matter (PM10) on Human Dermal Fibroblasts

SY Park, EJ Byun, JD Lee, S Kim, HS Kim - International journal of …, 2018 - mdpi.com
A World Health Organization (WHO) report from 2016 states that over 3 million people die
annually from air pollution, which places air pollution as the world's largest single …

Autophagy induction regulates aquaporin 3‐mediated skin fibroblast ageing

H Xie, L Zhou, F Liu, J Long, S Yan… - British Journal of …, 2022 - academic.oup.com
Background Long‐and short‐term ultraviolet (UV) exposure have distinct biological effects
on human fibroblasts. Objectives To elucidate the underlying mechanisms of the biological …

Impairment of the autophagy system in repetitively UVA‐irradiated fibroblasts

K Endo, Y Katsuyama, N Taira… - Photodermatology …, 2020 - Wiley Online Library
Background Autophagy is known as an intracellular cleanup system necessary to maintain
homeostasis of the skin. Many studies have pointed out the relationship between aging and …

Integrating DNA damage response and autophagy signalling axis in ultraviolet-B induced skin photo-damage: a positive association in protecting cells against …

SA Umar, SA Tasduq - RSC advances, 2020 - pubs.rsc.org
The skin acts as both physical as well as an immunological barrier against hazardous
agents from the outside environment and protects the internal organs against damage. Skin …