Mechanism of Sophorae Flavescentis Radix (Kushen) in treating NSCLC: Insights from miRNA-mRNA network analysis

J Li, Y Huang, J Xu, H Zuo, Y Tang, HY Huang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Sophorae Flavescentis Radix (Kushen) is the
primary herb component of Compound Kushen Injection (CKI), an approved clinical …

Sanguisorba officinalis L. suppresses non-small cell lung cancer via downregulating the PI3K/AKT/mTOR signaling pathway based on network pharmacology and …

H Li, J Lin, F Yang, J Deng, J Lai, J Zeng… - Frontiers in …, 2022 - frontiersin.org
Background: Non-small cell lung cancer (NSCLC) is the most common type of lung cancer.
Sanguisorba officinalis L.(SOL), a traditional Chinese herbal medicine called Diyu, has been …

Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …

D Luo, X Dai, H Tian, C Fan, H Xie, N Chen, J Wang… - Phytomedicine, 2023 - Elsevier
Background Novel compounds and more efficient treatment options are urgently needed for
the treatment of non-small cell lung cancer (NSCLC). The decoction of Sophora flavescens …

Integrated Network Pharmacology and Experimental Verification to explore the molecular mechanism of Hedysarum Multijugum Maxim–Curcumae Rhizoma Herb Pair …

S Hu, M Ge, S Zhang, M Jiang, K Hu, L Gao - Frontiers in Oncology, 2022 - frontiersin.org
Background Hedysarum Multijugum Maxim–Curcumae Rhizoma (HMMCR), a well-known
herb pair in traditional Chinese medicine (TCM), has been widely used for the treatment of …

Network pharmacology analysis, molecular docking integrated experimental verification reveal β-sitosterol as the active anti-NSCLC ingredient of Polygonatum …

W Cao, F Yuan, T Liu, R Yin - Journal of Ethnopharmacology, 2024 - Elsevier
Abstract Ethnopharmacological relevance Polygonatum cyrtonema Hua (Huangjing) is a
Chinese herb that is considered by ancient Chinese healers to have the effect of nourishing …

[HTML][HTML] Cytological effects of honokiol treatment and its potential mechanism of action in non-small cell lung cancer

J Zhang, Y Zhang, W Shen, R Fu, Z Ding, Y Zhen… - Biomedicine & …, 2019 - Elsevier
Purpose In this study, we aimed to explore key micro (mi) RNAs and their potential
regulatory mechanisms induced by honokiol treatment in non-small cell lung cancer …

Study on the material basis and action mechanisms of sophora davidii (Franch.) skeels flower extract in the treatment of non-small cell lung cancer

B Ye, P Chen, C Lin, C Zhang, L Li - Journal of Ethnopharmacology, 2023 - Elsevier
Abstract Ethnopharmacological relevance Sophora davidii (Franch.) Skeels Flower (SDF) is
a characteristic folk medicine in Yunnan and Guizhou, which can be used to prevent the …

Saucerneol attenuates nasopharyngeal carcinoma cells proliferation and metastasis through selectively targeting Grp94

Y Cheng, Q Wang, Z Zhang, C Zhao, H Zhou, J Xu… - Phytomedicine, 2022 - Elsevier
Background Nasopharyngeal carcinoma (NPC) is highly prevalent in southern China. The
remote metastasis of advanced NPC requires chemotherapeutic treatments to reduce the …

[HTML][HTML] The anti-cancerous mechanism of licochalcone A on human hepatoma cell HepG2 based on the miRNA omics

J Wang, X Zhang, Z Ni, E Elam, K Thakur, K Li… - Food Science and …, 2023 - Elsevier
To explore the function of licochalcone A as an anticancer phytochemical on HepG2 cells
and investigate its potential mechanisms, we analyzed the microRNAs (miRNAs) expression …

[HTML][HTML] Chloroform extract from Sophora Tonkinensis Gagnep. inhibit proliferation, migration, invasion and promote apoptosis of nasopharyngeal carcinoma cells by …

Z Song, X Gong, C Ou, W Zhang, J Wang, C Yao… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Sophora Tonkinensis Gagnep.(STG) has been
used as a folk medicine for the treatment of different cancers, especially for nasopharyngeal …