Recent reports have shown that IL-21, in synergy with IL-15, stimulates proliferation of CD8+
T lymphocytes in the absence of signaling via the TCR. In this study, we show that IL-6 …

Interleukin (IL)-7 is a cytokine essential for T lymphocyte development and homeostasis.
However, little is known about the roles of IL-7 receptor α-chain (IL-7Rα) in late stages of T …

Interleukin‐7 (IL‐7) is required for the development and survival of T cells and plays a critical
role in modulating T‐cell homeostasis. This review will address current understanding of IL …

Interleukin (IL)-7 is required for T-cell development as well as for the survival and
homeostasis of mature T-cells. In the thymus, the double negative (DN) CD4− CD8 …

T cell proliferation and survival are regulated by the cytokine receptor common γ-chain-
associated cytokines IL-2, IL-7, and IL-15, while IL-4, another γ-chain-associated cytokine, is …

The maintenance of naive CD8+ T cells is necessary for lifelong immunocompetence but for
unknown reasons requires signaling via both interleukin 7 (IL-7) and the T cell antigen …

This study examines the influence of IL‐7 on post‐thymic CD4+ T cells using cord blood as a
model system. Survival of naive cord blood T cells in the presence of IL‐7 alone was …

ABSTRACT Interleukin-7 (IL-7) regulates T-cell homeostasis, and its availability is
augmented in lymphopenic hosts. Naive CD8+ T cells transferred to lymphopenic mice …

The signaling processes that maintain the homeostatic proliferation of peripheral T-cells and
result in their self-renewal largely remain to be elucidated. Much focus has been placed on …

Abstract Interleukin-7 (IL-7), the principal cytokine implicated in thymopoiesis and peripheral
T-cell homeostasis, is presently under evaluation in human diseases characterized by …