GBR12909 (GBR) is a high‐affinity, selective, and long‐acting inhibitor of dopamine (DA)
uptake that produces a persistent and noncompetitive blockade of DA transporters and …

Rationale: Inhibitors of neuronal dopamine uptake, such as GBR 12909, decrease IV
cocaine self-administration by laboratory animals and have been proposed as potential …

Investigation of residual behavioral states produced by withdrawal from different routes of
cocaine administration indicates that depending on the mode of intake, chronic cocaine …

The chronic continuous infusion of cocaine produces partial behavioral tolerance to cocaine
and tolerance to the inhibition of dopamine uptake by cocaine, without changing dopamine …

Abstract C57BL/6 and DBA/2 mice were used to examine genetic differences in locomotor
activating effects of acute cocaine administration and to determine whether differences were …

Abstract Both 3-and 4-substituted GBR 12783 derivatives were synthesized in an effort to
create site-directed cocaine antagonists. The potencies of these compounds to inhibit …

Although some behavioral effects of cocaine are hypothesized to be due to blockade of
dopamine uptake in nucleus accumbens, it has been reported that in nucleus accumbens …

Extensive evidence suggests that the reinforcing effects of cocaine involve inhibition of
dopamine transporters (DAT) and subsequent increases in dopamine (DA) levels in the …

At the present time, there are no drugs are approved in the US for the treatment of stimulant
abuse. Based on a diverse body of preclinical data, sometimes termed the “dopamine …

Repeated administration of cocaine will cross-sensitize the locomotor response to a variety
of psychomotor stimulants. The ability of cocaine to cross-sensitize the locomotor effects of …