Although previous studies have demonstrated delayed viral clearance and blunted effector T
cell responses in aged mice during infection, memory CD8 T cells and especially secondary …

Aging is associated with altered immune responses, particularly with a diminished CD8 T
cell response. Although both intrinsic and extrinsic factors are hypothesized to impact this …

Aging is associated with suboptimal CD8 T cell responses to viral infections. It is not clear
whether these poor responses are due to environmental influences or quantitative and …

The mechanisms responsible for the diminished immune response seen with aging are
unclear. In this study, we investigate the contributions of alterations in the lymphoid …

Age-related declines in immune function have an impact on both primary and memory
responses. In this study, we have examined the ability of naive CD4 T cells from young and …

Aging is associated with depressed naive T cell responses, but it is less clear whether T cell
memory established early in life also becomes impaired with age. This is particularly …

ABSTRACT T cell exhaustion and loss of memory potential occur during many chronic viral
infections and cancer. We investigated when during chronic viral infection virus-specific CD8 …

Immune responsiveness declines with age in part due to the development of CD8+ T cell
clonal expansions (TCEs) that can dominate the peripheral T cell pool. Although some TCEs …

Memory CD8 T cells persist by Ag-independent homeostatic proliferation. To examine the
dynamics of this cell turnover, we transferred lymphocytic choriomeningitis virus specific …

Aging is associated with decreased expansion of T cells upon stimulation. In young mice,
infection induces a transient T cell depletion followed by the development of an Ag-specific T …