Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …

Regulation of antioxidant gene expression is essential for controlling oxidative stress and
maintaining physiological homeostasis. In this context, the nuclear factor E2-related factor 2 …

The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …

The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …

Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

Redox balance is essential to maintain the body's normal metabolism. Once disrupted, it
may lead to various chronic diseases, such as diabetes, neurodegenerative diseases …

Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …

Oxidative stress is the increase in cellular oxidant concentration in comparison to antioxidant
titer. Toxic insults and many other diseased conditions are mediated through the formation of …