Abstract Left-handed Z-DNA/Z-RNA is bound with high affinity by the Zα domain protein
family that includes ADAR (a double-stranded RNA editing enzyme), ZBP1 and viral …

Nucleic acids are powerful triggers of innate immunity and can adopt the Z-conformation, an
unusual left-handed double helix. Here, we studied the biological function (s) of Z-RNA …

The Zα domains represent a growing subfamily of the winged helix-turn-helix (HTH) domain
family whose members share a remarkable ability to bind specifically to Z-DNA and/or Z …

Variants in the human double-stranded RNA editing enzyme ADAR produce three well-
characterized rare Mendelian Diseases: Dyschromatosis Symmetrica Hereditaria (OMIM …

Abstract Adenosine-to-inosine (A-to-I) editing of eukaryotic cellular RNAs is essential for
protection against auto-immune disorders. Editing is carried out by ADAR1, whose innate …

Loss of function of adenosine deaminase acting on double-stranded RNA (dsRNA)-1
(ADAR1) causes the severe autoinflammatory disease Aicardi-Goutières syndrome (AGS) …

Double-stranded RNA (dsRNA) is produced both by virus and host. Its recognition by the
melanoma differentiation–associated gene 5 (MDA5) initiates type I interferon responses …

The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA.
Currently, little is known about the detailed structural features of Z-RNA or its involvement in …

Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases
associated with chronic activation of type I interferon (IFN) responses, including Aicardi …

Z-DNA is a high energy conformer of B-DNA that forms in vivo during transcription as a result
of torsional strain generated by a moving polymerase. An understanding of the biological …