The attributes of specificity and memory enable CD8+ T cells to provide long-lasting
protection against a variety of challenges. Although, the importance of CD8+ T cells for …

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in
tumor medicine, as many tumors express specific tumor associated antigens that are …

The adaptive immune system plays a pivotal role in the host's ability to mount an effective,
antigen‐specific immune response against tumors. CD8+ tumor‐infiltrating lymphocytes …

Research over the past decade has revealed the increasingly complex biologic features of
the CD4+ T-cell lineage. This T-cell subset, which was originally defined on the basis of …

Cytolytic CD8+ effector cells fall into two subpopulations based on cytokine secretion. Type
1 CD8+ T cells (Tc1) secrete IFN-γ, whereas type 2 CD8+ T cells (Tc2) secrete IL-4, IL-5, and …

Our understanding of the importance of CD4+ T cells in orchestrating immune responses
has grown dramatically over the past decade. This lymphocyte family consists of diverse …

CD4+ T cells have been shown to be able to affect tumor growth through both direct and
indirect means. In addition, a requirement has been demonstrated for CD4+ T cells in the …

The importance of CD4 T cells in orchestrating the immune system and their role in inducing
effective T cell-mediated therapies for the treatment of patients with select established …

Activation of CD8+ cytotoxic T cells has long been regarded as a major antitumor
mechanism of the immune system. Emerging evidence suggests that CD4+ T cells are …

CD4+ T cells are crucial in generating and sustaining immune responses. They orchestrate
and fine-tune mammalian innate and adaptive immunity through cell-based interactions and …