Genetic and epigenetic studies in different cancers, including cutaneous carcinomas, have
implicated T-cadherin (T-cad) as a tumor suppressor. Immunohistochemical and in vitro …

Mechanisms underlying cutaneous squamous cell carcinoma (SCC) tumour growth and
invasion are incompletely understood. Our previous pathological and in vitro studies …

Background Cadherins play important roles in controlling keratinocyte growth, differentiation
and survival. Atypical glycosylphosphatidylinositol‐anchored T‐cadherin (T‐cad) is highly …

Reciprocal cross-talk between receptor tyrosine kinases (RTKs) and classical cadherins (eg
EGFR/E-cadherin, VEGFR/VE-cadherin) has gained appreciation as a combinatorial …

T-cadherin is a unique member of the cadherin superfamily that lacks the transmembrane
and cytoplasmic domains, and is instead linked to the cell membrane via a glycosyl …

T-cadherin is gaining recognition as a determinant for the development of incipient invasive
squamous cell carcinoma (SCC). However, effects of T-cadherin expression on the …

E-cadherin, a cell–cell adhesion glycoprotein, is frequently downregulated with tumorigenic
progression. The extracellular domain of E-cadherin is cleaved by proteases to generate a …

T‐cadherin is a glycosyl‐phosphatidylinositol (GPI) anchored cadherin molecule. We
previously reported that T‐cadherin is normally expressed on the basal keratinocytes of the …

Classical cadherins are single-pass transmembrane glycoproteins engaged in homophilic
calcium-dependent cell-cell adhesion complexes, a system highly conserved in all …

E-cadherin was originally viewed exclusively as a structural protein mediating cell-cell
adhesion. More recently, its signaling functions have been recognized. Loss or …