Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies
S Niewiesk - Frontiers in immunology, 2014 - frontiersin.org
Neonates have an immature immune system, which cannot adequately protect against
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …
infectious diseases. Early in life, immune protection is accomplished by maternal antibodies …
Vaccination of neonates: problem and issues
DC Hodgins, PE Shewen - Vaccine, 2012 - Elsevier
Many serious infectious diseases occur early in life; efficacious vaccination of neonates has
been a longstanding goal in both human and veterinary medicine. Efforts to immunize in the …
been a longstanding goal in both human and veterinary medicine. Efforts to immunize in the …
[HTML][HTML] Maternal antibodies and infant immune responses to vaccines
KM Edwards - Vaccine, 2015 - Elsevier
Infants are born with immature immune systems, making it difficult for them to effectively
respond to the infectious pathogens encountered shortly after birth. Maternal antibody is …
respond to the infectious pathogens encountered shortly after birth. Maternal antibody is …
Insights into the regulatory mechanism controlling the inhibition of vaccine-induced seroconversion by maternal antibodies
D Kim, D Huey, M Oglesbee… - Blood, The Journal of …, 2011 - ashpublications.org
The inhibition of vaccination by maternal antibodies is a widely observed phenomenon in
human and veterinary medicine. Maternal antibodies are known to suppress the B-cell …
human and veterinary medicine. Maternal antibodies are known to suppress the B-cell …
Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
CA Siegrist - Vaccine, 2003 - Elsevier
Several mechanisms have been suggested as mediating the inhibitory influence of maternal
antibodies (MatAb) on infant responses. This inhibition is B cell determinant-specific …
antibodies (MatAb) on infant responses. This inhibition is B cell determinant-specific …
Determinants of infant responses to vaccines in presence of maternal antibodies
CA Siegrist, M Córdova, C Brandt, C Barrios, M Berney… - Vaccine, 1998 - Elsevier
Presence of maternally-derived antibodies at time of immunization is known to often interfere
with active infant immunization, although with variable degrees of clinical significance. In …
with active infant immunization, although with variable degrees of clinical significance. In …
The protective role of maternal immunization in early life
B Cinicola, MG Conti, G Terrin, M Sgrulletti… - Frontiers in …, 2021 - frontiersin.org
With birth, the newborn is transferred from a quasi-sterile environment to the outside world.
At this time, the neonatal immune system is inexperienced and continuously subject to a …
At this time, the neonatal immune system is inexperienced and continuously subject to a …
Influence of maternal antibodies on vaccine responses: inhibition of antibody but not T cell responses allows successful early prime‐boost strategies in mice
CA Siegrist, C Barrios, X Martinez… - European journal of …, 1998 - Wiley Online Library
The transfer of maternal antibodies to the offspring and their inhibitory effects on active infant
immunization is an important factor hampering the use of certain vaccines, such as measles …
immunization is an important factor hampering the use of certain vaccines, such as measles …
Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early-life B cell repertoire within germinal centers
M Vono, CS Eberhardt, F Auderset, B Mastelic-Gavillet… - Cell reports, 2019 - cell.com
Maternal antibodies (MatAbs) protect offspring from infections but limit their responses to
vaccination. The mechanisms of this inhibition are still debated. Using murine early-life …
vaccination. The mechanisms of this inhibition are still debated. Using murine early-life …
The multifaceted roles of breast milk antibodies
C Atyeo, G Alter - Cell, 2021 - cell.com
Neonates are born with an immature immune system and rely on the transfer of immunity
from their mothers. Maternal antibodies are transferred via the placenta and breast milk …
from their mothers. Maternal antibodies are transferred via the placenta and breast milk …
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