Alzheimer's disease (AD) is the most common neurological disease, which is associated
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by severe
cognitive deficits and pathologically by amyloid plaques, neuronal loss, and neurofibrillary …

Background: The early phase of Alzheimer's disease (AD) involves the disruption of finely
tuned neuronal circuitry in brain regions associated with learning and memory. This tuning is …

The early stages of Alzheimer's disease (AD) have been linked to microcircuit dysfunction
and pathophysiological neuronal firing in several brain regions. Inhibitory GABAergic …

Alzheimer's disease (AD) is characterized by the classical hallmarks of Aβ-deposition and
tau-pathology that are thought to ultimately lead to synapse and neuron loss. Although long …

Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …

Several lines of evidence imply changes in inhibitory interneuron connectivity and
subsequent alterations in oscillatory network activities in the pathogenesis of Alzheimer's …

Synaptic dysfunction is widely proposed as an initial insult leading to the neurodegeneration
observed in Alzheimer's disease (AD). We hypothesize that the initial insult originates in the …

Work on acute models of cortical injury has revealed a population of small GABAergic
interneurons that are induced to increase their low constitutive expression of neuronal nitric …

Selective negative allosteric modulators (NAMs), targeting α5 subunit-containing GABAA
receptors (GABAARs) as potential therapeutic targets for disorders associated with cognitive …