Background mcr-1-positive Escherichia coli has emerged as a significant threat to human
health, veterinary health, and food safety in recent years. After the prohibition of colistin as a …

Considering the serious threat to food safety and public health posed by pathogens with
colistin resistance, colistin was banned as a growth promoter in 2017 in China. In recent …

Abstract Objectives In November 2015, a plasmid-mediated colistin resistance, MCR-1, was
described in animals, food and humans in China, and it was considered as a potential …

Colistin is one of the last-line drugs against difficult to treat and multidrug-resistant Gram-
negative bacteria. The emergence of mobile colistin resistance gene m cr-1 increased …

Background The global dissemination of colistin resistance encoded by mcr-1 has been
attributed to extensive use of colistin in livestock, threatening colistin efficacy in medicine …

The mcr-1 gene is a plasmid-borne and globally distributed colistin-resistance gene, which
threatens the last-line role of colistin in treatment of infections caused by multi-drug resistant …

Colistin is used to treat infectious diseases in humans and livestock; it has also been used
as a feed additive for livestock for approximately 50 years. Since the mcr-1 plasmid …

The emergence and dissemination of colistin resistance in Enterobacteriaceae mediated by
plasmid-borne mcr genes in recent years now pose a threat to public health. In this study, we …

The emergence of the plasmid-mediated colistin resistance gene mcr-1 is threatening the
last-line role of colistin in human medicine. With mcr-1-positive Escherichia coli (E. coli) …

The emergence and global distribution of the mcr-1 gene for colistin resistance have
become a public concern because of threats to the role of colistin as the last line of defense …