Chronic pain, which affects around 1/3 of the world population and is often comorbid with
memory deficit and mood depression, is a leading source of suffering and disability. Studies …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Inflammation is originated by tissue injury and triggers several biochemical reactions that
sensitize the nervous system for pain perception. Chronic inflammation induces adaptive …

Chronic pain is a refractory health disease worldwide causing an enormous economic
burden on individuals and society. Accumulating evidence suggests that inflammation in the …

Chronic pain is a serious public health problem with a strong affective-motivational
component that makes it difficult to treat. Most patients with chronic pain suffer from severe …

Chronic pain syndrome is a heterogeneous group of diseases characterized by several
pathological mechanisms. One in five adults in Europe may experience chronic pain. In …

Neuro-immune interactions contribute to the pathogenesis of neuropathic pain due to
peripheral nerve injury. A large body of preclinical evidence supports the idea that the …

Chronic pain is a prevalent and debilitating condition, conveying immense human burden.
Suffering is caused not only by painful symptoms, but also through psychopathological and …

Neuronal injury not only results in severe alteration in the function of primary sensory
neurons and their central projection pathway, but is also associated with a robust immune …

Investigation of the basic mechanisms of chronic pain not only provides insights into how the
brain processes and modulates sensory information but also provides the basis for …