Apixaban and rivaroxaban in obese patients treated for venous thromboembolism: drug levels and clinical outcomes

A Ballerie, RN Van, K Lacut, H Galinat, C Rousseau… - Thrombosis research, 2021 - Elsevier
Background Direct oral anticoagulants (DOAC) use remains challenging in obese patients
treated for Venous-Thrombo-Embolism (VTE) due to the paucity of prospective and …

[HTML][HTML] Rivaroxaban versus warfarin treatment among morbidly obese patients with venous thromboembolism: comparative effectiveness, safety, and costs

AC Spyropoulos, V Ashton, YW Chen, B Wu… - Thrombosis research, 2019 - Elsevier
Introduction Limited data exist on direct-acting oral anticoagulants in morbidly obese
patients with venous thromboembolism (VTE). We compared clinical and health/economic …

Effectiveness and safety of rivaroxaban versus warfarin in obese patients with acute venous thromboembolism: analysis of electronic health record data

OS Costa, J Beyer-Westendorf, V Ashton… - Journal of Thrombosis …, 2021 - Springer
There is limited data evaluating clinical outcomes of rivaroxaban versus warfarin in obese
patients with venous thromboembolism (VTE). Our objective was to evaluate the …

Effectiveness and safety of apixaban vs. warfarin in venous thromboembolism patients with obesity and morbid obesity

A Cohen, J Sah, T Lee, L Rosenblatt… - Journal of Clinical …, 2021 - mdpi.com
This study integrated 5 United States healthcare claims databases to evaluate the risk of
recurrent venous thromboembolism (VTE) and major bleeding (MB) among VTE patients …

Efficacy, safety, and exposure of apixaban in patients with high body weight or obesity and venous thromboembolism: insights from AMPLIFY

AT Cohen, S Pan, W Byon, BS Ilyas, T Taylor… - Advances in Therapy, 2021 - Springer
Introduction As a result of limited clinical data, guidelines do not recommend the use of non-
vitamin K antagonist oral anticoagulants in patients who weigh> 120 kg or have a body …

Management of venous thromboembolism in morbid obesity with rivaroxaban or warfarin

P Weaver, TH Ng, T Breeden… - Annals of …, 2022 - journals.sagepub.com
Background Rivaroxaban is a first-line option for the management of venous
thromboembolism (VTE). However, limited data are available regarding its effectiveness in …

Multi‐center retrospective study evaluating the efficacy and safety of apixaban versus warfarin for treatment of venous thromboembolism in patients with severe …

A Crouch, TH Ng, D Kelley, T Knight… - … : The Journal of …, 2022 - Wiley Online Library
Abstract Study Objective Direct oral anticoagulants are the standard of care for venous
thromboembolism (VTE) treatment. These agents are recommended regardless of patient …

Real life results of direct-acting oral anticoagulants recommended-dose in obese vs normal-weight patients with venous thromboembolism

JA Rueda-Camino, R Barba, S Otálora… - Thrombosis …, 2024 - Elsevier
Background There is scarce evidence on the effectiveness and safety of recommended-
dose direct acting oral anticoagulants (DOACs) in obese patients with venous …

Efficacy and safety of direct‐acting Oral anticoagulants (DOACs) in the overweight and obese

K Doucette, H Latif, A Vakiti, E Tefera… - Advances in …, 2020 - Wiley Online Library
Obesity plays an essential role in the safety of pharmacologic drugs. There is paucity of data
for direct oral anticoagulants (DOACs) in the obese, despite these agents becoming more …

[HTML][HTML] Apixaban is safe and effective in morbidly obese patients: a retrospective analysis of 390 patients with BMI≥ 40

Y Choi, M Kushnir, HH Billett - Blood, 2017 - Elsevier
Background: In patients with venous thromboembolism (VTE), warfarin had been considered
standard of care until the new direct oral anticoagulants (DOACs) were developed. Studies …