[HTML][HTML] SARS-CoV-2-specific T cells exhibit phenotypic features of helper function, lack of terminal differentiation, and high proliferation potential
Summary Convalescing coronavirus disease 2019 (COVID-19) patients mount robust T cell
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …
responses against SARS-CoV-2, suggesting an important role of T cells in viral clearance …
Identification of resident memory CD8+ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue
Cross-reactive CD4+ T cells that recognize severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed …
(SARS-CoV-2) are more commonly detected in the peripheral blood of unexposed …
[HTML][HTML] Identification and characterization of a SARS-CoV-2 specific CD8+ T cell response with immunodominant features
A Gangaev, SLC Ketelaars, OI Isaeva… - Nature …, 2021 - nature.com
The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and
there is an urgent need to map the landscape of immunogenic and immunodominant …
there is an urgent need to map the landscape of immunogenic and immunodominant …
T cell and antibody kinetics delineate SARS-CoV-2 peptides mediating long-term immune responses in COVID-19 convalescent individuals
Long-term immunological memory to severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is crucial for the development of population-level immunity, which is the aim …
(SARS-CoV-2) is crucial for the development of population-level immunity, which is the aim …
[HTML][HTML] COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses
A Bonifacius, S Tischer-Zimmermann, AC Dragon… - Immunity, 2021 - cell.com
Cellular and humoral immunity to SARS-CoV-2 is critical to control primary infection and
correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its …
correlates with severity of disease. The role of SARS-CoV-2-specific T cell immunity, its …
CD8+ T-cell responses in COVID-19 convalescent individuals target conserved epitopes from multiple prominent SARS-CoV-2 circulating variants
This study examined whether CD8+ T-cell responses from coronavirus disease 2019
convalescent individuals (n= 30) potentially maintain recognition of the major severe acute …
convalescent individuals (n= 30) potentially maintain recognition of the major severe acute …
[HTML][HTML] Impact of SARS-CoV-2 variants on the total CD4+ and CD8+ T cell reactivity in infected or vaccinated individuals
The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the
importance of addressing whether the total CD4+ and CD8+ T cell recognition is also …
importance of addressing whether the total CD4+ and CD8+ T cell recognition is also …
[HTML][HTML] SARS-CoV-2-specific CD4+ T cells are associated with long-term persistence of neutralizing antibodies
Understanding the decay and maintenance of long-term SARS-CoV-2 neutralizing
antibodies in infected or vaccinated people and how vaccines protect against other SARS …
antibodies in infected or vaccinated people and how vaccines protect against other SARS …
[HTML][HTML] Negligible impact of SARS-CoV-2 variants on CD4+ and CD8+ T cell reactivity in COVID-19 exposed donors and vaccinees.
The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive
immune responses to this virus. It is important to address whether also CD4+ and CD8+ T …
immune responses to this virus. It is important to address whether also CD4+ and CD8+ T …
The quality of SARS-CoV-2–specific T cell functions differs in patients with mild/moderate versus severe disease, and T cells expressing coinhibitory receptors are …
Understanding the function of SARS-CoV-2 Ag-specific T cells is crucial for the monitoring of
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …
antiviral immunity and vaccine design. Currently, both impaired and robust T cell immunity is …