[HTML][HTML] Identification of cross-reactive CD8+ T cell receptors with high functional avidity to a SARS-CoV-2 immunodominant epitope and its natural mutant variants
Despite the growing knowledge of T cell responses in COVID-19 patients, there is a lack of
detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a …
detailed characterizations for T cell-antigen interactions and T cell functions. Here, with a …
[HTML][HTML] Targets of T cell responses to SARS-CoV-2 coronavirus in humans with COVID-19 disease and unexposed individuals
Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development,
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …
interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of …
[HTML][HTML] Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant
The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron (B. 1.1. 529) variant of concern (VOC) has destabilized global efforts to control the …
Omicron (B. 1.1. 529) variant of concern (VOC) has destabilized global efforts to control the …
[HTML][HTML] Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …
CoV-2 infection remains unknown. Here, we present single-cell transcriptomic analysis of> …
[HTML][HTML] HCoV-and SARS-CoV-2 cross-reactive T cells in CVID patients
S Steiner, F Sotzny, S Bauer, IK Na… - Frontiers in …, 2020 - frontiersin.org
The inability of patients with CVID to mount specific antibody responses to pathogens has
raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role …
raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role …
[HTML][HTML] Activation or exhaustion of CD8+ T cells in patients with COVID-19
In addition to CD4+ T cells and neutralizing antibodies, CD8+ T cells contribute to protective
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
immune responses against SARS-CoV-2 in patients with coronavirus disease 2019 (COVID …
[HTML][HTML] Single-cell transcriptomic analysis of SARS-CoV-2 reactive CD4+ T cells
BJ Meckiff, C Ramírez-Suástegui… - Social Science …, 2020 - ncbi.nlm.nih.gov
The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-
CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic …
CoV-2 infection remains unknown. Here, we present large-scale single-cell transcriptomic …
[HTML][HTML] Pre-existing T cell-mediated cross-reactivity to SARS-CoV-2 cannot solely be explained by prior exposure to endemic human coronaviruses
T-cell-mediated immunity to SARS-CoV-2-derived peptides in individuals unexposed to
SARS-CoV-2 has been previously reported. This pre-existing immunity was suggested to …
SARS-CoV-2 has been previously reported. This pre-existing immunity was suggested to …
[HTML][HTML] Distinctive features of SARS-CoV-2-specific T cells predict recovery from severe COVID-19
J Neidleman, X Luo, AF George, M McGregor, J Yang… - Cell Reports, 2021 - cell.com
Although T cells are likely players in severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …
(SARS-CoV-2) immunity, little is known about the phenotypic features of SARS-CoV-2 …
Presence of SARS-CoV-2-reactive T cells in COVID-19 patients and healthy donors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a rapidly
unfolding pandemic, overwhelming health care systems worldwide 1. Clinical manifestations …
unfolding pandemic, overwhelming health care systems worldwide 1. Clinical manifestations …