Drug and polymer mixing status in amorphous solid dispersions, an important aspect with
regard to the physical stability and in vivo performance of such systems, was evaluated in …

Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …

Amorphous solid dispersions (ASDs), where an active pharmaceutical ingredient (API) is
dissolved in a polymer, are a favored formulation technique to achieve sufficient …

The processing parameters for HME have been evaluated and the impact of solid state
intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly …

In order to successfully utilize amorphous solid dispersions (ASDs) to enhance drug
delivery, it is essential to maintain the amorphous form of the drug during the manufacturing …

Amorphous solid dispersion (ASD) has been well known as a potential strategy to improve
the bioavailability and dissolution performance of poorly water-soluble drugs. The primary …

Abstract Hot-melt-extrusion (HME) is an enabling technology used for poorly soluble active
pharmaceutical ingredients (APIs) to increase the bioavailability by embedding the drug in a …

Driven by the new trend to build quality into products and reducing empiricism, small-scale
screening techniques have been frequently used to evaluate, thermodynamic of drug …

Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …