Evaluation on the drug–polymer mixing status in amorphous solid dispersions at the early stage formulation and process development
H Ma, DS Choi, YE Zhang, H Tian, N Shah… - Journal of …, 2013 - Springer
Drug and polymer mixing status in amorphous solid dispersions, an important aspect with
regard to the physical stability and in vivo performance of such systems, was evaluated in …
regard to the physical stability and in vivo performance of such systems, was evaluated in …
Physical stability of amorphous solid dispersions: a physicochemical perspective with thermodynamic, kinetic and environmental aspects
X Lin, Y Hu, L Liu, L Su, N Li, J Yu, B Tang… - Pharmaceutical …, 2018 - Springer
Abstract Purpose Amorphous solid dispersions (ASDs) have been widely used in the
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …
pharmaceutical industry for solubility enhancementof poorly water-soluble drugs. The …
The shelf life of ASDs: 1. Measuring the crystallization kinetics at humid conditions
F Wolbert, K Nikoleit, M Steinbrink… - Molecular …, 2022 - ACS Publications
Amorphous solid dispersions (ASDs), where an active pharmaceutical ingredient (API) is
dissolved in a polymer, are a favored formulation technique to achieve sufficient …
dissolved in a polymer, are a favored formulation technique to achieve sufficient …
Hot melt extrusion (HME) for amorphous solid dispersions: predictive tools for processing and impact of drug–polymer interactions on supersaturation
AL Sarode, H Sandhu, N Shah, W Malick… - European Journal of …, 2013 - Elsevier
The processing parameters for HME have been evaluated and the impact of solid state
intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly …
intermolecular drug–polymer interactions on supersaturation has been investigated. Poorly …
[图书][B] Physical stability and crystallization inhibition
LS Taylor - 2015 - books.google.com
In order to successfully utilize amorphous solid dispersions (ASDs) to enhance drug
delivery, it is essential to maintain the amorphous form of the drug during the manufacturing …
delivery, it is essential to maintain the amorphous form of the drug during the manufacturing …
Prediction and construction of drug-polymer binary system thermodynamic phase diagram in amorphous solid dispersions (ASDs)
Amorphous solid dispersion (ASD) has been well known as a potential strategy to improve
the bioavailability and dissolution performance of poorly water-soluble drugs. The primary …
the bioavailability and dissolution performance of poorly water-soluble drugs. The primary …
Adding a new dimension to the amorphous solid dispersion phase diagram: studying dissolution kinetics of crystalline drugs in a polymer matrix using temperature …
VK Seiler, F Theil, N Nagel, H van Lishaut - Journal of Pharmaceutical …, 2022 - Elsevier
Abstract Hot-melt-extrusion (HME) is an enabling technology used for poorly soluble active
pharmaceutical ingredients (APIs) to increase the bioavailability by embedding the drug in a …
pharmaceutical ingredients (APIs) to increase the bioavailability by embedding the drug in a …
Are traditional small-scale screening methods reliable to predict pharmaceutical spray drying?
S Poozesh, S Mahdi Jafari - Pharmaceutical development and …, 2019 - Taylor & Francis
Driven by the new trend to build quality into products and reducing empiricism, small-scale
screening techniques have been frequently used to evaluate, thermodynamic of drug …
screening techniques have been frequently used to evaluate, thermodynamic of drug …
The implications of drug-polymer interactions on the physical stability of amorphous solid dispersions
M Bookwala, PLD Wildfong - Pharmaceutical Research, 2023 - Springer
Amorphous solid dispersions (ASDs) are a formulation and development strategy that can
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …
be used to increase the apparent aqueous solubility of poorly water-soluble drugs. Their …
Thermodynamic modeling of the amorphous solid dispersion-water interfacial layer and its impact on the release mechanism
S Dohrn, SO Kyeremateng, E Bochmann, E Sobich… - Pharmaceutics, 2023 - mdpi.com
During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …
forms at the ASD/water interface strongly dictates the release of the active pharmaceutical …