Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule
drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form …

Application of amorphous solid dispersions (ASDs) is considered one of the most promising
approaches to increase the dissolution rate and extent of bioavailability of poorly water …

The solubility of a drug is ultimately governed by its chemical potential as it is present in the
undissolved solute. For a pharmaceutical amorphous solid dispersion (ASD), its solubility …

The maximum achievable concentration of a drug in solution is dictated by the chemical
potential of the solid form. Because an amorphous solid has a higher chemical potential …

Using phase diagrams derived from Flory–Huggins theory, we defined the thermodynamic
state of amorphous felodipine within three different polymeric carriers. Variation in the …

Intermolecular interactions between active pharmaceutical ingredients (APIs) and carrier
polymers are important for the long-term physical stability of amorphous solid dispersions …

The incorporation of poorly soluble active pharmaceutical ingredients (APIs) into excipients
(eg, polymers) to formulate an amorphous solid dispersion is a promising strategy to …

The purpose of this study was to determine the drug-polymer miscibility of GENE-A, a
Genentech molecule, and hydroxypropyl methylcellulose-acetate succinate (HPMC-AS), a …

Amorphous solid dispersion (ASD) is a preparation widely used for improving the solubility
and low oral absorbability of poorly water-soluble drugs, but the quantitative analysis of its …

The most common drawback of the existing and novel drug molecules is their low
bioavailability because of their low solubility. One of the most important approaches to …