Molecular-level examination of amorphous solid dispersion dissolution
MA Faiz Afzal, K Lehmkemper, E Sobich… - Molecular …, 2021 - ACS Publications
Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule
drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form …
drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form …
Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations
Application of amorphous solid dispersions (ASDs) is considered one of the most promising
approaches to increase the dissolution rate and extent of bioavailability of poorly water …
approaches to increase the dissolution rate and extent of bioavailability of poorly water …
Solubility advantage (and disadvantage) of pharmaceutical amorphous solid dispersions
S Huang, C Mao, RO Williams III, CY Yang - Journal of pharmaceutical …, 2016 - Elsevier
The solubility of a drug is ultimately governed by its chemical potential as it is present in the
undissolved solute. For a pharmaceutical amorphous solid dispersion (ASD), its solubility …
undissolved solute. For a pharmaceutical amorphous solid dispersion (ASD), its solubility …
Tailoring supersaturation from amorphous solid dispersions
The maximum achievable concentration of a drug in solution is dictated by the chemical
potential of the solid form. Because an amorphous solid has a higher chemical potential …
potential of the solid form. Because an amorphous solid has a higher chemical potential …
An investigation into the role of polymeric carriers on crystal growth within amorphous solid dispersion systems
Using phase diagrams derived from Flory–Huggins theory, we defined the thermodynamic
state of amorphous felodipine within three different polymeric carriers. Variation in the …
state of amorphous felodipine within three different polymeric carriers. Variation in the …
Polymer-inducing chemical degradation of amorphous solid dispersions driven by drug-polymer interactions for physical stabilization
T Kojima, J Takeda, Y Song, K Yamamoto… - International Journal of …, 2023 - Elsevier
Intermolecular interactions between active pharmaceutical ingredients (APIs) and carrier
polymers are important for the long-term physical stability of amorphous solid dispersions …
polymers are important for the long-term physical stability of amorphous solid dispersions …
Influence of copolymer composition on the phase behavior of solid dispersions
A Prudic, T Kleetz, M Korf, Y Ji… - Molecular …, 2014 - ACS Publications
The incorporation of poorly soluble active pharmaceutical ingredients (APIs) into excipients
(eg, polymers) to formulate an amorphous solid dispersion is a promising strategy to …
(eg, polymers) to formulate an amorphous solid dispersion is a promising strategy to …
A rational approach towards development of amorphous solid dispersions: experimental and computational techniques
P Chakravarty, JW Lubach, J Hau… - International Journal of …, 2017 - Elsevier
The purpose of this study was to determine the drug-polymer miscibility of GENE-A, a
Genentech molecule, and hydroxypropyl methylcellulose-acetate succinate (HPMC-AS), a …
Genentech molecule, and hydroxypropyl methylcellulose-acetate succinate (HPMC-AS), a …
Theoretical evaluation of supersaturation of amorphous solid dispersion formulations with different drug/polymer combinations using mathematical modeling
D Hirai, H Tsunematsu, S Kimura, S Itai… - International Journal of …, 2022 - Elsevier
Amorphous solid dispersion (ASD) is a preparation widely used for improving the solubility
and low oral absorbability of poorly water-soluble drugs, but the quantitative analysis of its …
and low oral absorbability of poorly water-soluble drugs, but the quantitative analysis of its …
Stability challenges of amorphous solid dispersions of drugs: A critical review on mechanistic aspects
The most common drawback of the existing and novel drug molecules is their low
bioavailability because of their low solubility. One of the most important approaches to …
bioavailability because of their low solubility. One of the most important approaches to …