Herein, the thermodynamic properties of solutions evolving from the non-sink dissolution of
amorphous solid dispersions (ASDs) containing two or more drugs have been evaluated …

Despite the fact that an amorphous solid dispersion (ASD)-coated pellet formulation offers
potential advantages regarding the minimization of physical stability issues, there is still a …

Several literature publications have described the potential application of active
pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate …

Hot-melt extrusion is often used to prepare amorphous solid dispersion to overcome low
drug solubility and enhance bio-performance of the formulation. Due to the uniqueness of …

Purpose To identify molecular indicators of bulk and surface instabilities of amorphous
dispersions prepared by hot melt extrusion. Methods Four model drugs with different …

Amorphous solid dispersions (ASDs) have emerged as widespread formulations for drug
delivery of poorly soluble active pharmaceutical ingredients (APIs). Predicting the API …

The purpose of this work is to compare the long-term physical stability of amorphous solid
dispersion (ASD) formulations based on three different commercially used excipients …

The formulation of oral amorphous solid dispersions (ASD) includes the use of excipients to
improve physical stability and enhance bioavailability. Combinations of excipients (polymers …

Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …