Simultaneous Water Sorption and Crystallization in ASDs 2: Modeling Long-Term Stabilities
B Grönniger, E Fritschka, K Kimpe… - Molecular …, 2024 - ACS Publications
The physical stability of amorphous solid dispersions (ASDs) is a major topic in the
formulation research of oral dosage forms. To minimize the effort of investigating the long …
formulation research of oral dosage forms. To minimize the effort of investigating the long …
Impact of polymer type and relative humidity on the long-term physical stability of amorphous solid dispersions
K Lehmkemper, SO Kyeremateng… - Molecular …, 2017 - ACS Publications
The purpose of this work is to compare the long-term physical stability of amorphous solid
dispersion (ASD) formulations based on three different commercially used excipients …
dispersion (ASD) formulations based on three different commercially used excipients …
Supersaturation and crystallization: non-equilibrium dynamics of amorphous solid dispersions for oral drug delivery
K Kawakami - Expert Opinion on Drug Delivery, 2017 - Taylor & Francis
ABSTRACT Introduction: Amorphous solid dispersions (ASDs) are one of the key
formulation technologies that aid the development of poorly soluble candidates. However …
formulation technologies that aid the development of poorly soluble candidates. However …
Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …
for delivering amorphous drugs with poor water solubilities, and they have gained great …
Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
solubility of poorly water-soluble drugs. However, achieving both physical stability and …
Impact of Polymer Enrichment at the Crystal–Liquid Interface on Crystallization Kinetics of Amorphous Solid Dispersions
J Zhang, Q Shi, J Tao, Y Peng, T Cai - Molecular Pharmaceutics, 2019 - ACS Publications
Amorphous solid dispersions have been widely used as an effective formulation strategy in
the oral delivery of poorly soluble drugs. However, one of the main challenges in the …
the oral delivery of poorly soluble drugs. However, one of the main challenges in the …
Miniaturized screening of polymers for amorphous drug stabilization (SPADS): rapid assessment of solid dispersion systems
N Wyttenbach, C Janas, M Siam, ME Lauer… - European Journal of …, 2013 - Elsevier
PURPOSE: Development of a novel, rapid, miniaturized approach to identify amorphous
solid dispersions with maximum supersaturation and solid state stability. METHOD: Three …
solid dispersions with maximum supersaturation and solid state stability. METHOD: Three …
The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the stability of amorphous solid dispersions
J Wu, G Van den Mooter - International Journal of Pharmaceutics, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the formulation strategies for drugs displaying
low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with …
low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with …
Drug-rich phases induced by amorphous solid dispersion: arbitrary or intentional goal in oral drug delivery?
Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …
Amorphous solid dispersions: Rational selection of a manufacturing process
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
most exciting areas in the pharmaceutical field. This approach presents huge potential and …