Simultaneous Water Sorption and Crystallization in ASDs 2: Modeling Long-Term Stabilities

B Grönniger, E Fritschka, K Kimpe… - Molecular …, 2024 - ACS Publications
The physical stability of amorphous solid dispersions (ASDs) is a major topic in the
formulation research of oral dosage forms. To minimize the effort of investigating the long …

Impact of polymer type and relative humidity on the long-term physical stability of amorphous solid dispersions

K Lehmkemper, SO Kyeremateng… - Molecular …, 2017 - ACS Publications
The purpose of this work is to compare the long-term physical stability of amorphous solid
dispersion (ASD) formulations based on three different commercially used excipients …

Supersaturation and crystallization: non-equilibrium dynamics of amorphous solid dispersions for oral drug delivery

K Kawakami - Expert Opinion on Drug Delivery, 2017 - Taylor & Francis
ABSTRACT Introduction: Amorphous solid dispersions (ASDs) are one of the key
formulation technologies that aid the development of poorly soluble candidates. However …

Amorphous solid dispersions: role of the polymer and its importance in physical stability and in vitro performance

Q Shi, H Chen, Y Wang, R Wang, J Xu, C Zhang - Pharmaceutics, 2022 - mdpi.com
Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …

Effects of additives on the physical stability and dissolution of polymeric amorphous solid dispersions: A review

J Li, Y Wang, D Yu - AAPS PharmSciTech, 2023 - Springer
Polymeric amorphous solid dispersion (ASD) is a popular approach for enhancing the
solubility of poorly water-soluble drugs. However, achieving both physical stability and …

Impact of Polymer Enrichment at the Crystal–Liquid Interface on Crystallization Kinetics of Amorphous Solid Dispersions

J Zhang, Q Shi, J Tao, Y Peng, T Cai - Molecular Pharmaceutics, 2019 - ACS Publications
Amorphous solid dispersions have been widely used as an effective formulation strategy in
the oral delivery of poorly soluble drugs. However, one of the main challenges in the …

Miniaturized screening of polymers for amorphous drug stabilization (SPADS): rapid assessment of solid dispersion systems

N Wyttenbach, C Janas, M Siam, ME Lauer… - European Journal of …, 2013 - Elsevier
PURPOSE: Development of a novel, rapid, miniaturized approach to identify amorphous
solid dispersions with maximum supersaturation and solid state stability. METHOD: Three …

The influence of hydrogen bonding between different crystallization tendency drugs and PVPVA on the stability of amorphous solid dispersions

J Wu, G Van den Mooter - International Journal of Pharmaceutics, 2023 - Elsevier
Amorphous solid dispersion (ASD) is one of the formulation strategies for drugs displaying
low solubility and low oral bioavailability. In this study, high drug-loaded ASDs of drugs with …

Drug-rich phases induced by amorphous solid dispersion: arbitrary or intentional goal in oral drug delivery?

K Qian, L Stella, DS Jones, GP Andrews, H Du, Y Tian - Pharmaceutics, 2021 - mdpi.com
Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

Amorphous solid dispersions: Rational selection of a manufacturing process

T Vasconcelos, S Marques, J das Neves… - Advanced drug delivery …, 2016 - Elsevier
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …