Studies to determine the etiology of osteosarcoma involve epidemiologic and environmental
factors and genetic impairments. Factors related to patient characteristics include age …

Despite the knowledge of many of the genetic alterations present in osteosarcoma, its
complexity precludes placing its biology into a simple conceptual framework. In contrast to …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

Osteosarcoma (OS) is the most common primary bone tumor affecting predominantly
adolescents and young adults. It accounts for about 5% of all childhood cancers. Although …

Background Individuals who had cancer in childhood are at higher risk of developing bone
cancer than any other type of second primary cancer. Purpose Using the population-based …

The histologic and clinical characteristics of 54 patients with osteosarcoma are reviewed.
The association of rapid linear bone growth with the occurrence of this tumor is confirmed …

Tumor-specific chromosomal abnormalities have been identified in several histologic
subtypes of sarcomas. Characterization of recurrent chromosomal abnormalities has …

We studied the pedigrees of 17 index patients with osteosarcoma, recording malignant
disease and cause of death for first-and second-degree relatives. There were seven cancers …

Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic
without a known genetic or environmental cause. Heritable genetic predisposition …

In 1969 Li and Fraumeni identified, from a systematic study of 648 children with
rhabdomyosarcomas, five families in which a sibling or a cousin was affected by sarcoma (Li …