Neutrophilic bronchiolitis is the primary lesion in asthma-affected horses. Neutrophils are
key actors in host defense, migrating toward sites of inflammation and infection, where they …

Asthma is a common and debilitating chronic airway disease that affects people and horses
of all ages worldwide. While asthma in humans most commonly involves an excessive type …

Asthma encompasses a spectrum of heterogenous immune-mediated respiratory disorders
sharing a similar clinical pattern characterized by cough, wheeze and exercise intolerance …

Background Neutrophil apoptosis and phagocytic clearance have been proposed as key
determinants affecting the resolution of airway inflammation. Objective To determine the …

Acute COPD was induced in susceptible horses by exposure to a 5 h hay/straw challenge.
The kinetics and function of airspace neutrophils harvested by bronchoalveolar lavage and …

Neutrophils are potent contributors to the lung pathophysiological changes occurring in
allergic airway inflammation, which typically involve T helper type 2 (Th2) cytokine …

Heaves, also known as recurrent airway obstruction, is a common condition of horses
characterised by pulmonary neutrophilia and reversible airway obstruction. This study …

Background: Pasture-associated severe equine asthma is a warm season, environmentally-
induced respiratory disease characterized by reversible airway obstruction, persistent and …

Animal models have been studied to unravel etiological, immunopathological, and genetic
attributes leading to asthma. However, while experiments in which the disease is artificially …

Background Severe neutrophilic asthma is poorly responsive to glucocorticosteroids (GC).
Neutrophil extracellular traps (NETs) within the lungs have been associated with the severity …