Brain ischemic stroke is one of the leading causes of death in developed countries,
including Japan. Controlling the neuroinflammation in the penumbra region with mild …

A strong therapeutic target of ischemic stroke is controlling brain inflammation. Recent
studies have implicated the critical role of CC chemokine receptor 5 (CCR5) in …

Background and purpose: The chemokine receptor CCR5 is well known for its function in
immune cells; however, it is also expressed in the brain, where its specific role remains to be …

Background: Stroke is the second leading cause of death and a major cause of disability of
adults worldwide. Inflammatory processes are known to contribute to the pathophysiology of …

We examined the role of CCRL2 in ischemic brain injury using both in vitro and in vivo
mouse stroke models. The expression of CCRL2 was enhanced at both the RNA and protein …

Background and Purpose—The chemokine, monocyte chemoattractant protein-1 (CCL2), is
a major factor driving leukocyte infiltration into the brain parenchyma in a variety of …

Ischemic stroke involves a series of complex pathological mechanisms, of which
neuroinflammation is currently the most widely recognized. C–C motif chemokine receptor 5 …

Abstract Chemokine (CC motif) receptor 5 (CCR5) is expressed not only in the immune cells
but also in cerebral cells such as neurons, glia, and vascular cells. Stroke triggers high …

Thirty percent of ischemic stroke patients develop vascular cognitive impairment and
dementia (VCID) within 1 year of stroke onset. The expression of CC motif chemokine …

CC motif chemokine ligand 2 (CCL2) is a member of the monocyte chemokine protein
family, which binds to its receptor CCR2 to induce monocyte infiltration and mediate …