Functional assessment of the acute local and distal transplantation of human neural stem cells after spinal cord injury
I Cheng, RE Mayle, CA Cox, DY Park, RL Smith… - The Spine Journal, 2012 - Elsevier
BACKGROUND CONTEXT: Spinal cord injury can lead to severe functional impairments
secondary to axonal damage, neuronal loss, and demyelination. The injured spinal cord has …
secondary to axonal damage, neuronal loss, and demyelination. The injured spinal cord has …
Local versus distal transplantation of human neural stem cells following chronic spinal cord injury
I Cheng, M Githens, RL Smith, TR Johnston, DY Park… - The Spine Journal, 2016 - Elsevier
Abstract Background Context Previous studies have demonstrated functional recovery of
rats with spinal cord contusions after transplantation of neural stem cells adjacent to the site …
rats with spinal cord contusions after transplantation of neural stem cells adjacent to the site …
[HTML][HTML] Does timing of transplantation of neural stem cells following spinal cord injury affect outcomes in an animal model?
I Cheng, DY Park, RE Mayle, M Githens… - Journal of Spine …, 2017 - ncbi.nlm.nih.gov
Background We previously reported that functional recovery of rats with spinal cord
contusions can occur after acute transplantation of neural stem cells distal to the site of …
contusions can occur after acute transplantation of neural stem cells distal to the site of …
Combined transplantation of human neuronal and mesenchymal stem cells following spinal cord injury
DY Park, RE Mayle, RL Smith… - Global Spine …, 2013 - journals.sagepub.com
Transplantation of human fetal neural stem cells (hNSCs) previously demonstrated
significant functional recovery after spinal cord contusion in rats. Other studies indicated that …
significant functional recovery after spinal cord contusion in rats. Other studies indicated that …
Neuroectodermal stem cells grafted into the injured spinal cord induce both axonal regeneration and morphological restoration via multiple mechanisms
Spinal cord contusion injury leads to severe loss of gray and white matter and subsequent
deficit of motor and sensory functions below the lesion. In this study, we investigated …
deficit of motor and sensory functions below the lesion. In this study, we investigated …
[PDF][PDF] Induction of functional recovery by co-transplantation of neural stem cells and Schwann cells in a rat spinal cord contusion injury model
J Li, CR Sun, H Zhang, KS Tsang, JH Li… - Biomedical and …, 2007 - besjournal.com
Objective To study the transplantation efficacy of neural stem cells (NSCs) and Schwann
cells (SC) in a rat model of spinal cord contusion injury. Methods Multipotent neural stem …
cells (SC) in a rat model of spinal cord contusion injury. Methods Multipotent neural stem …
Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation
S van Gorp, M Leerink, O Kakinohana… - Stem cell research & …, 2013 - Springer
Introduction Intraspinal grafting of human neural stem cells represents a promising approach
to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide …
to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide …
Stem cell-based cell therapy for spinal cord injury
BG Kim, DH Hwang, SI Lee, EJ Kim… - Cell …, 2007 - journals.sagepub.com
Traumatic injuries to the spinal cord lead to severe and permanent neurological deficits.
Although no effective therapeutic option is currently available, recent animal studies have …
Although no effective therapeutic option is currently available, recent animal studies have …
Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat
T Amemori, N Romanyuk, P Jendelova… - Stem cell research & …, 2013 - Springer
Introduction A growing number of studies have highlighted the potential of stem cell and
more-differentiated neural cell transplantation as intriguing therapeutic approaches for …
more-differentiated neural cell transplantation as intriguing therapeutic approaches for …
Optimal location and time for neural stem cell transplantation into transected rat spinal cord
Y Li, WM Zhang, TH Wang - Cellular and molecular neurobiology, 2011 - Springer
Implanted neural stem cells (NSC) could improve neurological functions following spinal
cord injury (SCI), but the optimal conditions for NSC transplantation are largely unknown …
cord injury (SCI), but the optimal conditions for NSC transplantation are largely unknown …
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