Functional assessment of the acute local and distal transplantation of human neural stem cells after spinal cord injury

I Cheng, RE Mayle, CA Cox, DY Park, RL Smith… - The Spine Journal, 2012 - Elsevier
BACKGROUND CONTEXT: Spinal cord injury can lead to severe functional impairments
secondary to axonal damage, neuronal loss, and demyelination. The injured spinal cord has …

Local versus distal transplantation of human neural stem cells following chronic spinal cord injury

I Cheng, M Githens, RL Smith, TR Johnston, DY Park… - The Spine Journal, 2016 - Elsevier
Abstract Background Context Previous studies have demonstrated functional recovery of
rats with spinal cord contusions after transplantation of neural stem cells adjacent to the site …

[HTML][HTML] Does timing of transplantation of neural stem cells following spinal cord injury affect outcomes in an animal model?

I Cheng, DY Park, RE Mayle, M Githens… - Journal of Spine …, 2017 - ncbi.nlm.nih.gov
Background We previously reported that functional recovery of rats with spinal cord
contusions can occur after acute transplantation of neural stem cells distal to the site of …

Combined transplantation of human neuronal and mesenchymal stem cells following spinal cord injury

DY Park, RE Mayle, RL Smith… - Global Spine …, 2013 - journals.sagepub.com
Transplantation of human fetal neural stem cells (hNSCs) previously demonstrated
significant functional recovery after spinal cord contusion in rats. Other studies indicated that …

Neuroectodermal stem cells grafted into the injured spinal cord induce both axonal regeneration and morphological restoration via multiple mechanisms

K Pajer, T Bellák, H Redl, A Nógrádi - Journal of Neurotrauma, 2019 - liebertpub.com
Spinal cord contusion injury leads to severe loss of gray and white matter and subsequent
deficit of motor and sensory functions below the lesion. In this study, we investigated …

[PDF][PDF] Induction of functional recovery by co-transplantation of neural stem cells and Schwann cells in a rat spinal cord contusion injury model

J Li, CR Sun, H Zhang, KS Tsang, JH Li… - Biomedical and …, 2007 - besjournal.com
Objective To study the transplantation efficacy of neural stem cells (NSCs) and Schwann
cells (SC) in a rat model of spinal cord contusion injury. Methods Multipotent neural stem …

Amelioration of motor/sensory dysfunction and spasticity in a rat model of acute lumbar spinal cord injury by human neural stem cell transplantation

S van Gorp, M Leerink, O Kakinohana… - Stem cell research & …, 2013 - Springer
Introduction Intraspinal grafting of human neural stem cells represents a promising approach
to promote recovery of function after spinal trauma. Such a treatment may serve to: I) provide …

Stem cell-based cell therapy for spinal cord injury

BG Kim, DH Hwang, SI Lee, EJ Kim… - Cell …, 2007 - journals.sagepub.com
Traumatic injuries to the spinal cord lead to severe and permanent neurological deficits.
Although no effective therapeutic option is currently available, recent animal studies have …

Human conditionally immortalized neural stem cells improve locomotor function after spinal cord injury in the rat

T Amemori, N Romanyuk, P Jendelova… - Stem cell research & …, 2013 - Springer
Introduction A growing number of studies have highlighted the potential of stem cell and
more-differentiated neural cell transplantation as intriguing therapeutic approaches for …

Optimal location and time for neural stem cell transplantation into transected rat spinal cord

Y Li, WM Zhang, TH Wang - Cellular and molecular neurobiology, 2011 - Springer
Implanted neural stem cells (NSC) could improve neurological functions following spinal
cord injury (SCI), but the optimal conditions for NSC transplantation are largely unknown …