[HTML][HTML] Genome-wide survey of the GATA gene family in camptothecin-producing plant Ophiorrhiza pumila
M Shi, Q Huang, Y Wang, C Wang, R Zhu, S Zhang… - BMC genomics, 2022 - Springer
Abstract Background Ophiorrhiza pumila (Rubiaceae) is capable of producing camptothecin
(CPT), one monoterpene indole alkaloid extensively employed in the treatment of multiple …
(CPT), one monoterpene indole alkaloid extensively employed in the treatment of multiple …
[HTML][HTML] Genome-wide identification and comparative analysis of the teosinte branched 1/cycloidea/proliferating cell factors 1/2 transcription factors related to anti …
C Wang, X Hao, Y Wang, M Shi, ZG Zhou… - Frontiers in Plant …, 2021 - frontiersin.org
Ophiorrhiza pumila (O. pumila; Op) is a medicinal herbaceous plant, which can accumulate
camptothecin (CPT). CPT and its derivatives are widely used as chemotherapeutic drugs for …
camptothecin (CPT). CPT and its derivatives are widely used as chemotherapeutic drugs for …
[HTML][HTML] Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila
M Yang, Q Wang, Y Liu, X Hao, C Wang, Y Liang… - BMC biology, 2021 - Springer
Background The anticancer drug camptothecin (CPT), first isolated from Camptotheca
acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila …
acuminata, was subsequently discovered in unrelated plants, including Ophiorrhiza pumila …
OpNAC1 transcription factor regulates the biosynthesis of the anticancer drug camptothecin by targeting loganic acid O‐methyltransferase in Ophiorrhiza pumila
X Hao, C Wang, W Zhou, Q Ruan, C Xie… - Journal of Integrative …, 2023 - Wiley Online Library
Camptothecin (CPT) is an anticancer pentacyclic quinoline alkaloid widely used to treat
cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation …
cancer patients worldwide. However, the biosynthetic pathway and transcriptional regulation …
Integrated transcriptome and proteome analysis provides new insights into camptothecin biosynthesis and regulation in Camptotheca acuminata
H Zhang, X Shen, S Sun, Y Li, S Wang… - Physiologia …, 2023 - Wiley Online Library
Camptotheca acuminata Decne., the main source of camptothecin (CPT), has received
increasing attention for its remarkable antitumor activity. Many CPT derivatives are clinically …
increasing attention for its remarkable antitumor activity. Many CPT derivatives are clinically …
[HTML][HTML] Pyrosequencing of the Camptotheca acuminata transcriptome reveals putative genes involved in camptothecin biosynthesis and transport
Y Sun, H Luo, Y Li, C Sun, J Song, Y Niu, Y Zhu… - BMC genomics, 2011 - Springer
Background Camptotheca acuminata is a Nyssaceae plant, often called the" happy tree",
which is indigenous in Southern China. C. acuminata produces the terpenoid indole …
which is indigenous in Southern China. C. acuminata produces the terpenoid indole …
Genome-wide identification and analysis of AP2/ERF transcription factors related to camptothecin biosynthesis in Camptotheca acuminata
HU Ya-Ting, XU Zhi-Chao, T Ya, GAO Ran-Ran… - Chinese journal of …, 2020 - Elsevier
Camptotheca acuminata produces camptothecin (CPT), a monoterpene indole alkaloid
(MIA) that is widely used in the treatment of lung, colorectal, cervical, and ovarian cancers …
(MIA) that is widely used in the treatment of lung, colorectal, cervical, and ovarian cancers …
[HTML][HTML] Integrative Analysis of Elicitor-Induced Camptothecin Biosynthesis in Camptotheca acuminata Plantlets Through a Combined Omics Approach
X Pu, HC Gao, MJ Wang, JH Zhang, JH Shan… - Frontiers in Plant …, 2022 - frontiersin.org
Treatments with abiotic elicitors can efficiently induce the accumulation of specialized
metabolites in plants. We used a combined omics approach to analyze the elicitation effects …
metabolites in plants. We used a combined omics approach to analyze the elicitation effects …
Targeted metabolic engineering of committed steps improves anti-cancer drug camptothecin production in Ophiorrhiza pumila hairy roots
M Shi, H Gong, L Cui, Q Wang, C Wang, Y Wang… - Industrial crops and …, 2020 - Elsevier
Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …
[HTML][HTML] A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
M Kang, R Fu, P Zhang, S Lou, X Yang, Y Chen… - Nature …, 2021 - nature.com
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …