Nerve growth factor (NGF) functions as a ligand for two receptors, the TrkA tyrosine kinase
receptor and the p75 neurotrophin receptor (p75NTR). The Ig-like domains of Trk receptors …

The neurotrophin receptor homolog (NRH2) is closely related to the p75 neurotrophin
receptor (p75NTR); however, its function and role in neurotrophin signaling are unclear …

The cellular response to nerve growth factor (NGF) is mediated by two structurally unrelated
receptors, TrkA and p75 neurotrophin receptor (p75NTR), which have been shown to …

Nerve growth factor binds independently to two transmembrane receptors, the p75
neurotrophin receptor and the p140trk (trkA) tyrosine kinase receptor, which are both co …

Nerve growth factor (NGF) is an important neuronal survival factor, especially during
development. Optimal sensitivity of the survival response to NGF requires the presence of …

Neurotrophins bind to two structurally unrelated receptors, the trk tyrosine kinases and the
neurotrophin receptor p75 NTR. Ligand activation of these two types of receptor can lead to …

Ligand-induced receptor oligomerization is an established mechanism for receptor-tyrosine
kinase activation. However, numerous receptor-tyrosine kinases are expressed in …

While the central role played by TrkA in nerve growth factor (NGF) signalling has been
established by dissecting its signal transduction pathways, insight into the mechanism of …

The low‐affinity p75 molecule and trk tyrosine kinases serve as receptors for target‐derived
neurotrophins. While the mechanism by which receptor tyrosine kinases impart intracellular …

Nerve growth factor (NGF) binds to two neurotrophin receptors: p75NTR and p140Trk (TrkA).
Both receptors dimerize in response to NGF binding. TrkA homodimers and heteromers of …