[HTML][HTML] IncobotulinumtoxinA for the treatment of spasticity in children with cerebral palsy–a retrospective case series focusing on dosing and tolerability

A León-Valenzuela, JS Palacios, R del Pino Algarrada - BMC neurology, 2020 - Springer
Abstract Background IncobotulinumtoxinA (Xeomin®) is a botulinum neurotoxin type A with
established efficacy in the treatment of upper-limb spasticity in adults. This retrospective …

[HTML][HTML] IncobotulinumtoxinA for the treatment of lower-limb spasticity in children and adolescents with cerebral palsy: A phase 3 study

F Heinen, P Kanovský, AS Schroeder… - Journal of pediatric …, 2021 - content.iospress.com
PURPOSE: Investigate the efficacy and safety of multipattern incobotulinumtoxinA injections
in children/adolescents with lower-limb cerebral palsy (CP)-related spasticity. METHODS …

[HTML][HTML] IncobotulinumtoxinA efficacy/safety in upper-limb spasticity in pediatric cerebral palsy: Randomized controlled trial

E Dabrowski, HG Chambers, D Gaebler-Spira… - Pediatric …, 2021 - Elsevier
Background This randomized, phase 3 study with double-blind main period (MP) and open-
label extension (OLEX; NCT02002884) assessed incobotulinumtoxinA safety and efficacy …

Safety profile of incobotulinum toxin A [Xeomin®] in gastrocnemious muscles injections in children with cerebral palsy: Randomized double-blind clinical trial

E Carraro, E Trevisi, A Martinuzzi - European Journal of Paediatric …, 2016 - Elsevier
Background The only two preparations of botulinum toxin A for which there are published
evidences of efficacy in children with cerebral palsy are onabotulinum toxin A (Botox®) and …

Clinical and pharmacological properties of incobotulinumtoxinA and its use in neurological disorders

WH Jost, R Benecke, D Hauschke… - Drug Design …, 2015 - Taylor & Francis
Background IncobotulinumtoxinA (Xeomin®) is a purified botulinum neurotoxin type A
formulation, free from complexing proteins, with proven efficacy and good tolerability for the …

[HTML][HTML] Safety profile and lack of immunogenicity of incobotulinumtoxinA in pediatric spasticity and sialorrhea: A pooled analysis

S Berweck, M Banach, D Gaebler-Spira, HG Chambers… - Toxins, 2022 - mdpi.com
IncobotulinumtoxinA, a pure botulinumtoxinA formulation, is free of accessory proteins. This
analysis provides pooled safety data from phase 3 trials of children/adolescents (2–17 …

[HTML][HTML] Safety and efficacy of repeat long-term incobotulinumtoxinA treatment for lower limb or combined upper/lower limb spasticity in children with cerebral palsy

P Kaňovský, F Heinen, AS Schroeder… - Journal of pediatric …, 2022 - content.iospress.com
PURPOSE: The open-label phase 3 “Treatment with IncobotulinumtoxinA in Movement
Open-Label”(TIMO) study investigated longer-term safety and efficacy of …

Botulinum toxin for spasticity in children with cerebral palsy: a comprehensive evaluation

K Bjornson, R Hays, C Graubert, R Price, F Won… - …, 2007 - publications.aap.org
BACKGROUND. Spasticity is a prevalent disabling clinical symptom for children with
cerebral palsy. Treatment of spasticity with botulinum toxin in children with cerebral palsy …

IncobotulinumtoxinA: a review in upper limb spasticity

YN Lamb, LJ Scott - Drugs, 2016 - Springer
Abstract Intramuscular incobotulinumtoxinA (Xeomin®) is indicated for the treatment or
improvement of adult patients with upper limb spasticity (featured indication), cervical …

Factors predicting the efficacy of botulinum toxin-A treatment of the lower limb in children with cerebral palsy

E Fazzi, I Maraucci, S Torrielli… - Journal of child …, 2005 - journals.sagepub.com
Botulinum toxin A is widely used for spasticity management in children with cerebral palsy,
although outcomes are unpredictable. The aim of this study was to identify criteria for …