Oral colon-targeting core–shell microparticles loading curcumin for enhanced ulcerative colitis alleviating efficacy

C Zhang, Z Chen, Y He, J Xian, R Luo, C Zheng… - Chinese Medicine, 2021 - Springer
Background The oral colon-targeting drug delivery vehicle is vital for the efficient application
of curcumin (Cur) in ulcerative colitis (UC) treatment because of its lipophilicity and instability …

[HTML][HTML] Nano-in-micro alginate/chitosan hydrogel via electrospray technology for orally curcumin delivery to effectively alleviate ulcerative colitis

C Zhang, X Wang, M Xiao, J Ma, Y Qu, L Zou, J Zhang - Materials & Design, 2022 - Elsevier
Although nano-systems can promote the cellular internalization, polymeric nanoparticles
(NPs) are easily to be destroyed or eliminated in the gastrointestinal tract, which leads to …

Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy

B Xiao, X Si, M Zhang, D Merlin - Colloids and Surfaces B: Biointerfaces, 2015 - Elsevier
Oral colon-specific drug delivery is of great interest for ulcerative colitis (UC) therapy. Here,
an emulsion-solvent evaporation method was used to fabricate microparticles (MPs) with pH …

Oral colon-targeted mucoadhesive micelles with enzyme-responsive controlled release of curcumin for ulcerative colitis therapy

C Zhang, J Li, M Xiao, D Wang, Y Qu, L Zou… - Chinese Chemical …, 2022 - Elsevier
Although multitudinous nanoscale drug-delivery systems (DDSs) have been recommended
to improve anti-ulcerative colitis (UC) outcomes, to enhance the mucoadhesion of …

Co-delivery of resveratrol and curcumin based on Mesona chinensis polysaccharides/zein nanoparticle for targeted alleviation of ulcerative colitis

J Yang, X Chen, J Lin, M Shen, Y Wang, A Sarkar… - Food Bioscience, 2024 - Elsevier
Herein, a novel oral nano-delivery system (CR-NPs) was designed for co-delivering
curcumin and resveratrol to treat ulcerative colitis (UC) using Mesona chinensis …

Oral delivery of curcumin via porous polymeric nanoparticles for effective ulcerative colitis therapy

Q Chen, X Si, L Ma, P Ma, M Hou, S Bai… - Journal of Materials …, 2017 - pubs.rsc.org
Oral drug delivery has been considered as a promising strategy for ulcerative colitis (UC)
therapy. Here, an emulsion solvent evaporation technique was employed to prepare non …

Facile fabrication of bowl-shaped microparticles for oral curcumin delivery to ulcerative colitis tissue

Q Chen, S Gou, Y Huang, X Zhou, Q Li, MK Han… - Colloids and Surfaces B …, 2018 - Elsevier
Oral microparticles (MPs) have been considered as promising drug carriers in the treatment
of ulcerative colitis (UC). Here, a facile strategy based on a conventional emulsion-solvent …

Curcumin nanocrystal/pH-responsive polyelectrolyte multilayer core–shell nanoparticles for inflammation-targeted alleviation of ulcerative colitis

MA Oshi, J Lee, M Naeem, N Hasan, J Kim… - …, 2020 - ACS Publications
In this study, we developed oral core–shell nanoparticles composed of curcumin
nanocrystals in the core and chitosan/alginate multilayers in the shell for inflammation …

Oral administration of chondroitin sulfate-functionalized nanoparticles for colonic macrophage-targeted drug delivery

X Zhang, Y Ma, L Ma, M Zu, H Song, B Xiao - Carbohydrate polymers, 2019 - Elsevier
Orally targeted delivery of anti-inflammatory drugs to macrophages has attracted great
attention for minimizing the symptoms of ulcerative colitis (UC). In this investigation, we …

Oral drug delivery systems for ulcerative colitis therapy: A comparative study with microparticles and nanoparticles

P Ma, X Si, Q Chen, L Ma, M Hou, Z Xu… - Current cancer drug …, 2019 - ingentaconnect.com
Background: Oral administrations of microparticles (MPs) and nanoparticles (NPs) have
been widely employed as therapeutic approaches for the treatment of ulcerative colitis (UC) …