Kidney diseases impart a vast burden on affected individuals and the overall health care
system. Progressive loss of renal parenchymal cells and functional decline following injury …

Notch is a critical regulator of kidney development, but the pathway is mostly silenced once
kidney maturation is achieved. Recent reports demonstrated increased expression of Notch …

Background Kidney injuries that result in chronic inflammation initiate crosstalk between
stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor …

Acute kidney injury is a major risk factor for subsequent chronic renal and/or cardiovascular
complications. Previous studies have shown that Notch3 was de novo expressed in the …

Notch receptors and their canonical ligands are transmembrane proteins of the EGF‐like
family, expressed in the cell surface. Notch receptors are synthesized as single peptides and …

Notch3 expression is found in the glomerular podocytes of patients with lupus nephritis or
focal segmental GN but not in normal kidneys. Here, we show that activation of the Notch3 …

Notch signalling is a highly conserved cell–cell communication mechanism that regulates
development, tissue homeostasis, and repair. Within the kidney, Notch has an important …

Background The Notch pathway is indispensable for glomerular development. Nephrons
without glomeruli and proximal tubules are observed in animal models with absent receptor …

Kidney development involves formation of nephrons intricately aligned with the vasculature
and connected to a branched network of collecting ducts. Notch signaling plays multiple …

Episodes of acute renal failure (ARF) are not always fully reversible and may lead to chronic
disease, due in part to an inadequate regenerative response. The Notch signaling pathway …