Diabetic nephropathy (DN) is a metabolic disease characterized by mesangial cell
proliferation and extracellular matrix (ECM) accumulation. Salidroside (SAL) is the major …

Diabetes mellitus (DM) is a high-impact disease commonly characterized by hyperglycemia,
inflammation, and oxidative stress. Diabetic nephropathy (DN) is a common diabetic …

Аbstrаct This work aims to investigate the renal effect of hydrogen sulfide (H2S), in the
experimentally induced diabetic nephropathy, besides the role of activation of АТP‐sensitive …

Diabetic nephropathy is characterized as the progressive development of renal insufficiency
in a setting of hyperglycemia. Previous studies indicate that reactive oxygen species (ROS) …

DN is recognized as not only a leading cause of end stage renal disease (ESRD) but also
an independent risk factor for cardiovascular disease (CVD). Novel therapeutic approaches …

OBJECTIVE: The aim of the present study was to assess the effects of rosuvastatin on renal
injury and inflammation in a model of nitric oxide deficiency. METHODS: Male Wistar rats …

Background: Persistent chronic hyperglycemia is an important player in the development
and progression of diabetic nephropathy (DN) due to generation of oxidative stress (OS) …

Objectives: To assess the reno-protective effect of rosuvastatin on gentamicin-induced
nephrotoxicity in rats. Methods: The prospective experimental study was conducted at the …

Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in the world.
Several signaling pathways are involved in the pathogenesis of DN including elevation in …

Renal hypertrophy and extracellular matrix accumulation are early features of diabetic
nephropathy. Hyperglycemia-induced oxidative stress is implicated in the etiology of …