Defects in insulin secretion by pancreatic cells and/or decreased sensitivity of target tissues
to insulin action are the key features of type 2 diabetes. It has been shown that excessive …

High glucose-induced oxidative stress and increased NADPH oxidase-2 (NOX2) activity
may contribute to the progressive decline of the functional β-cell mass in type 2 diabetes. To …

In insulin-secreting cells, expression of NADPH oxidase (NOX), a potent source of ROS, has
been reported, along with controversial findings regarding its function. Here, the role of …

Redox stress related loss of beta cell function is a feature of diabetes. Exposure of beta cells
and islets to inflammatory mediators elevates reactive oxygen species (ROS) and beta cell …

It is now widely accepted that reactive oxygen species (ROS) contribute to cell and tissue
dysfunction and damage in diabetes. The source of ROS in the insulin secreting pancreatic …

Increased intracellular generation of reactive oxygen species [ROS] has been implicated in
the pathology of metabolic [diabetes] and neurodegenerative [Alzheimer's] diseases …

In type 2 diabetes, it has been proposed that pancreatic beta-cell dysfunction is promoted by
oxidative stress caused by NADPH oxidase (NOX) overactivity. Five different NOX enzymes …

Aims: Nicotinamide adenine dinucleotide phosphate oxidases (NOX-es) produce reactive
oxygen species and modulate β-cell insulin secretion. Islets of type 2 diabetic subjects …

In type 2 diabetes, metabolic stress has a negative impact on pancreatic β-cell function and
survival (T2D). Although the pathogenesis of metabolic stress is complex, an imbalance in …

Background: Increased levels of plasma cholesterol are a common feature of patient of type
2 diabetes. However, the links between elevated levels of low-density lipoprotein (LDL) and …