Aromatic amines have been shown to cause bladder cancer. However, epithelial cells of the
urinary bladder, cells of origin of bladder cancer, may be exposed to numerous substances …

Abstract The cytochrome P450 CYP1A1 and CYP1B1 enzymes are phase I extrahepatic
enzymes involved in the activation of pro-carcinogenic compounds to carcinogenic …

It was evident that nitrosamines can act directly on target tissue and result in carcinogenesis.
As has been shown, the carcinogenic activity of nitrosamines relied on its bioactivation by …

Expression of cytochromes P450 CYP1A1, CYP1B1, CYP2E1 and CYP4B1 was analysed
on the transcript level in human urothelial cells obtained by various methods. As a source of …

The potential for metabolic activation of bladder carcinogens by the bladder mucosa was
examined by determining if bladder mucosa microsomes contain cytochrome P-450, exhibit …

In 2019, lung cancer was estimated to be the leading cause of cancer deaths in humans.
Polycyclic aromatic hydrocarbons (PAHs) are known to increase the risk of lung cancer …

The rat CYP2B gene subfamily includes CYP2B1, CYP2B2 and CYP2B3. Translation of an
alternatively spliced hepatic CYP2B2 mRNA would generate a CYP2B2 variant, CYP2B2v …

Abstract Cytochrome P4501A1 (CYP1A1) is involved in the bioactivation of polycyclic
aromatic hydrocarbons into their reactive epoxide metabolites. CYP1A1 is considered to be …

Aminobiphenyl (ABP) is a trace component of cigarette smoke and hair dyes, a suspected
human carcinogen and a potent rodent liver carcinogen. Postnatal exposure of mice to ABP …

The cytochrome P4501A (CYP1A) enzymes play important roles in the metabolic activation
and detoxification of numerous environmental carcinogens, including polycyclic aromatic …