Dendritic cells are powerful antigen-presenting cells that are essential for the priming of T
cell responses. In addition to providing T-cell-receptor ligands and co-stimulatory molecules …

Previous in vivo studies established that inactivated Francisella tularensis immune
complexes (mAb-iFt) are a more protective vaccine against lethal tularemia than iFt alone …

A complex mechanism may be operational for dendritic cell (DC) maturation, wherein Toll-
like receptor and other signaling pathways may be coordinated differently depending on the …

Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive
immune response, and different DC can have markedly different (eg, opposing) function …

Dendritic cells (DCs) are specialized antigen presenting cells that are exquisitely adapted to
sense pathogens and induce the development of adaptive immune responses. They form a …

Innate immunity and adaptive immunity consist of highly specialized immune lineages that
depend on transcription factors for both function and development. In this review, we dissect …

The transcription factor, interferon regulatory factor-8 (IRF8), is required for the development
of monocytes, macrophages, dendritic cells (DCs), basophils, and eosinophils, while it …

Dendritic cells (DCs) are innate immune cells of the myeloid lineage that are specialized at
pathogen recognition, cytokine production, and antigen presentation. Their functions and …

Dendritic cells (DCs) are specialized innate immune cells that sense pathogen-associated
signals via pattern recognition receptors, including the TLRs, and subsequently stimulate …

The ability of dendritic cells (DCs) to initiate and regulate adaptive immune responses is
fundamental for maintaining immune homeostasis upon exposure to self or foreign antigens …