Background Alzheimer's disease is a complex neurodegenerative disorder characterized
pathologically by a temporal and spatial progression of beta-amyloid (Aβ) deposition …

Inflammatory mediators, such as tumor necrosis factor-α (TNF-α) and interleukin-1beta,
appear integral in initiating and/or propagating Alzheimer's disease (AD)-associated …

Background Inflammation is believed to play an important role in the pathology of
Alzheimer's disease (AD) and cytokine production is a key pathologic event in the …

Chronic brain inflammation is associated with Alzheimer's disease (AD) and is classically
attributed to amyloid plaque deposition. However, whether the amyloid pathology can trigger …

Inflammation is a critical component of the pathogenesis of Alzheimer's disease (AD).
Although not an initiator of this disorder, inflammation nonetheless plays a pivotal role as a …

Neuroinflammation is a conspicuous feature of Alzheimer disease (AD) pathology and is
thought to contribute to the ultimate neurodegeneration that ensues. IL-1β has emerged as a …

Microglia are the primary immune cell of the brain and function to protect the central nervous
system (CNS) from injury and invading pathogens. In the homeostatic brain, microglia serve …

Alzheimer's disease (AD) is the most common form of dementia, characterized by
accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and …

Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …

Background Neuroinflammation has long been considered a driver of Alzheimer's disease
progression. However, experiments developed to explore the interaction between …