Blood vessel endothelium has been recently shown to induce endocrine pancreatic
development [1]. Because pancreatic endocrine cells or islets express high levels of …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

Aims/hypothesis Vascular endothelial growth factor (VEGF) is essential for proper pancreatic
development, islet vascularisation and insulin secretion. In the adult pancreas, VEGF is …

Microvascular development is determined by the interplay between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly …

There is a reciprocal interaction between pancreatic islet cells and vascular endothelial cells
(EC) in which EC-derived signals promote islet cell differentiation and islet development …

To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic …

VEGF-A expression in beta cells is critical for pancreatic development, formation of islet-
specific vasculature, and Insulin secretion. However, two key questions remain. First, is …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

The pancreatic islets are one of the most vascularized organs of the body. This likely reflects
the requirements of the organ for a rich supply of nutrients and oxygen to the tissue, as well …

Endocrine and exocrine pancreatic morphogenesis is known to occur from ductal
epithelium, but the factors that regulate this process are unknown. Vascular endothelial …