We have examined the ability of KW‐6002, an adenosine A2a antagonist, to modulate the
dyskinetic effects of l‐DOPA in 6‐hydroxydopamine‐lesioned rats. In animals rendered …

The adenosine A 2A receptor antagonist SCH 58261 increases the turning behavior
induced by L-dopa in unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rats. In this study …

In order to investigate the role of adenosine A2A receptor blockade on dopamine-mediated
motor responses, contralateral turning behaviour and expression of the early-gene c-fos was …

Adenosine A2a antagonists can modulate dopamine-mediated motor behaviours, however,
their ability to induce rotational behaviour in 6-hydroxydopamine (6-OHDA)-lesioned rats …

Several evidences indicate that the selective blockade of adenosine A2A receptors
counteracts the motor activity impairment in experimental models of Parkinson's disease. In …

Dopamine D2 and adenosine A2A receptors interact to regulate aspects of motor and
motivational function, and it has been suggested that adenosine A2A antagonists could be …

Evidence obtained in rodent and primate models of Parkinson's disease (PD) and
preliminary clinical trials, indicates that adenosine A2A receptor antagonists might represent …

In rats with unilateral 6‐hydroxydopamine lesions of the dopaminergic nigrostriatal pathway,
administration of the A2a adenosine antagonist SCH 58261 alone did not induce any motor …

To determine whether the adenosine A2A receptor might play a role in L‐DOPA‐induced
dyskinesia in Parkinson's disease, we analyzed changes in the expression of A2A receptor …

The most effective treatment of Parkinson's disease (PD) is, at present, the dopamine
precursor L-3, 4-dihydroxyphenyl-alanine (L-DOPA), however a number of disadvantages …