In the present study, we investigate the hypothesis that mitochondrial oxidative damage and
dysfunction precede the onset of neuronal loss after controlled cortical impact traumatic …

Traumatic brain injury (TBI) is a major cause of death and disability in the United States and
causes mitochondrial damage leading to impaired brain function. The purpose of this review …

Conclusions Over the last thirty years, therapeutic strategies targeting mitochondrial
dysfunction in TBI have focused on metabolic dysregulation, MPTP formation, and oxidative …

The mitochondrion is a double membrane structured organelle involved in a variety of
regulatory functions such as calcium signaling, production of adenosine triphosphate …

Following traumatic brain injury (TBI), mitochondrial function becomes compromised.
Mitochondrial dysfunction is characterized by intra-mitochondrial Ca2+ accumulation …

Pioglitazone, an FDA-approved compound, has been shown to target the novel
mitochondrial protein mitoNEET and produce short-term neuroprotection and functional …

Experimental traumatic brain injury (TBI) results in a significant loss of cortical tissue at the
site of injury, and in the ensuing hours and days a secondary injury exacerbates this primary …

Mitochondrial dysfunction is known to occur following traumatic brain injury (TBI) and has
been well characterized. This study assessed possible age-related changes in the cortical …

We recently documented the progressive nature of mitochondrial dysfunction over 24 hr after
contusion spinal cord injury (SCI), but the underlying mechanism has not been elucidated …

Mild traumatic brain injury (mTBI) is a significant national health concern and there is
growing evidence that repetitive mTBI (rmTBI) can cause long-term change in brain structure …