Background: The epidemiology of pertussis is changing, with a clear increase in the number
of cases diagnosed in adolescents and adults. This development has spurred studies and …

States and other countries in which infants and children are universally immunized. 1–3
Presently, this “resurgence” of pertussis is presented with alarm in frequent newspaper …

Acellular pertussis vaccines provide protection against whooping cough with few adverse
effects. Their introduction to routine immunisation programmes would be facilitated by their …

A diphtheria and tetanus toxoid two-component acellular pertussis vaccine (DTaP),
consisting of 25 μg glutaraldehyde-detoxified pertussis toxin (PT) and 25 μg native …

Highly effective vaccines have been available for the prevention of pertussis for over 50
years. Universal immunization of infants and young children has resulted in dramatic …

Despite the wealth of information on the pathogenesis, virulence and antigenicity of
Bordetalla pertussis and the successful development of e# icacious acellular pertussis …

All acellular pertussis vaccines contain pertussis toxoid and induce protection against
pertussis. This study investigated the relation between the postvaccination levels of …

Objectives: The primary objective was to assess the nature and incidence of adverse events
after a fourth dose of a tricomponent acellular pertussis-diphtheria-tetanus vaccine given in …

B. pertussis is a human-specific pathogen and the causative agent of whooping cough. The
ongoing resurgence in pertussis incidence in high income countries is likely due to faster …

The performance of four acellular pertussis vaccines containing between two and five
pertussis antigens combined with diphtheria and tetanus toxoids was compared with that of …