The physiological functioning of the brain is not well-known in current day medicine and the
pathologies of many neuropsychiatric disorders are still not yet fully understood. With our …

Purpose A limit on developing new treatments for a number of central nervous system (CNS)
disorders has been the inadequate understanding of the in vivo pathophysiology underlying …

Over the past 35 years or so, PET brain imaging has allowed powerful and unique insights
into brain function under normal conditions and in disease states. Initially, as PET …

The goal of any early central nervous system (CNS) drug development program is always to
test the mechanism and not the molecule in order to support additional research investments …

Early applications of positron emission tomography (PET) in psychiatry sought to identify
derangements of cerebral blood flow and metabolism. The need for more specific …

Rationale This review attempts to summarize the current status in relation to the use of
positron emission tomography (PET) imaging in the assessment of synaptic concentrations …

The serotonergic system plays a key modulatory role in the brain and is the target for many
drug treatments for brain disorders either through reuptake blockade or via interactions at …

The development of functional brain nuclear medicine techniques and their application in
the investigation of neuropsychiatric disorders, have contributed significantly in the …

Neuroscientists of today dispose of a powerful armament for functional, physiological, and
molecular imaging that has never made more impressive advances than before, helping to …

As drug discovery and development in Neuroscience push beyond symptom management
to disease modification, neuroimaging becomes a key area of translational research that …