Fen1 mutations result in autoimmunity, chronic inflammation and cancers
Functional deficiency of the FEN1 gene has been suggested to cause genomic instability
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …
Overexpression and Hypomethylation of Flap Endonuclease 1 Gene in Breast and Other Cancers
Abstract Flap endonuclease 1 (FEN1) is a structure-specific nuclease best known for its
critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA …
critical roles in Okazaki fragment maturation, DNA repair, and apoptosis-induced DNA …
Haploinsufficiency of Flap endonuclease (Fen1) leads to rapid tumor progression
M Kucherlapati, K Yang, M Kuraguchi… - Proceedings of the …, 2002 - National Acad Sciences
F lap e ndo n uclease (Fen1) is required for DNA replication and repair, and defects in the
gene encoding Fen1 cause increased accumulation of mutations and genome …
gene encoding Fen1 cause increased accumulation of mutations and genome …
Functional regulation of FEN1 nuclease and its link to cancer
L Zheng, J Jia, LD Finger, Z Guo, C Zer… - Nucleic acids …, 2011 - academic.oup.com
Abstract Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
Z Guo, L Zheng, H Xu, H Dai, M Zhou… - Nature chemical …, 2010 - nature.com
Abstract Flap endonuclease 1 (FEN1), a structure-specific endo-and exonuclease, has
multiple functions that determine essential biological processes, such as cell proliferation …
multiple functions that determine essential biological processes, such as cell proliferation …
Flap endonuclease 1: a novel tumour suppresser protein
G Henneke, E Friedrich-Heineken… - Trends in biochemical …, 2003 - cell.com
Abstract Flap endonuclease 1 (Fen1) is a key enzyme for maintaining genetic stability in
eukaryotic genomes. Haploinsufficiency of Fen1 leads to the rapid progression of tumours in …
eukaryotic genomes. Haploinsufficiency of Fen1 leads to the rapid progression of tumours in …
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination
E Guo, Y Ishii, J Mueller, A Srivatsan… - Proceedings of the …, 2020 - National Acad Sciences
Synthetic lethality strategies for cancer therapy exploit cancer-specific genetic defects to
identify targets that are uniquely essential to the survival of tumor cells. Here we show …
identify targets that are uniquely essential to the survival of tumor cells. Here we show …
Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner
Overexpression of the flap endonuclease FEN1 has been observed in a variety of cancer
types and is a marker for poor prognosis. To better understand the cellular consequences of …
types and is a marker for poor prognosis. To better understand the cellular consequences of …
Vertebrate cells lacking FEN‐1 endonuclease are viable but hypersensitive to methylating agents and H2O2
Y Matsuzaki, N Adachi, H Koyama - Nucleic acids research, 2002 - academic.oup.com
The structure‐specific FEN‐1 endonuclease has been implicated in various cellular
processes, including DNA replication, repair and recombination. In vertebrate cells …
processes, including DNA replication, repair and recombination. In vertebrate cells …
[HTML][HTML] Overexpression of flap endonuclease 1 correlates with enhanced proliferation and poor prognosis of Non–Small-Cell lung cancer
Flap endonuclease 1 (FEN1) plays a crucial role in both DNA replication and damage
repair. In this study, FEN1 expression and its clinical-pathologic significance in non–small …
repair. In this study, FEN1 expression and its clinical-pathologic significance in non–small …